Biologically Active Small Molecules

A potent and selective inhibitor of HDAC6 (IC₅₀ = 0.002 nM, as compared with 271, 252, 0.

A potent and selective inhibitor of HDAC6 (IC₅₀ = 0.002 nM, as compared with 271, 252, 0.

A potent, reversible inhibitor of 5-LO, in cell-free assays (IC₅₀ = 86 nM), intact neutrophils (IC₅₀ = 230 nM), and in whole blood (IC₅₀ = 830 nM) significantly reduces both LT biosynthesis and inflammatory

A potent, reversible inhibitor of 5-LO, in cell-free assays (IC₅₀ = 86 nM), intact neutrophils (IC₅₀ = 230 nM), and in whole blood (IC₅₀ = 830 nM) significantly reduces both LT biosynthesis and inflammatory

Binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site (IC50 = 30 nM) inhibits the proliferation of several cancer cell lines (IC50 ~ 0.28 &muM), promotes the degradation of Hsp90 client proteins, and

Binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site (IC50 = 30 nM) inhibits the proliferation of several cancer cell lines (IC50 ~ 0.28 &muM), promotes the degradation of Hsp90 client proteins, and

Binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site (IC50 = 30 nM) inhibits the proliferation of several cancer cell lines (IC50 ~ 0.28 &muM), promotes the degradation of Hsp90 client proteins, and

A propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC₅₀ = 50 nM) does not inhibit other NMDA subunits, AMPA receptors, or kainate receptors has neuroprotective effects in

A propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC₅₀ = 50 nM) does not inhibit other NMDA subunits, AMPA receptors, or kainate receptors has neuroprotective effects in

A propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC₅₀ = 50 nM) does not inhibit other NMDA subunits, AMPA receptors, or kainate receptors has neuroprotective effects in

A propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC₅₀ = 50 nM) does not inhibit other NMDA subunits, AMPA receptors, or kainate receptors has neuroprotective effects in

An antagonist of lipid A activation of TLR4 (IC₅₀ =1.68 &muM), in a cell-based assay significantly improves survival of mice given intraperitoneal LPS.