Biologically Active Small Molecules

An alcohol related to a C32:6 very long chain fatty acid found in the retina its biological actions are unknown.

A TZD derivative that inhibits 15-PGDH activity with an IC₅₀ value of 31 nM.

A TZD derivative that inhibits 15-PGDH activity with an IC₅₀ value of 31 nM.

A TZD derivative that inhibits 15-PGDH activity with an IC₅₀ value of 31 nM.

A TZD derivative that inhibits 15-PGDH activity with an IC₅₀ value of 31 nM.

Inhibits recombinant human and mouse sEH (IC50s both = 0.4 nM) and demonstrates a 1,000-fold increase in potency compared to morphine in reducing hyperalgesia in an in vivo carrageenan-induced inflammatory pain model.

Inhibits recombinant human and mouse sEH (IC50s both = 0.4 nM) and demonstrates a 1,000-fold increase in potency compared to morphine in reducing hyperalgesia in an in vivo carrageenan-induced inflammatory pain model.

Inhibits recombinant human and mouse sEH (IC50s both = 0.4 nM) and demonstrates a 1,000-fold increase in potency compared to morphine in reducing hyperalgesia in an in vivo carrageenan-induced inflammatory pain model.

An aryl-benzoyl-imidazole which prevents proliferation of multidrug resistant cancer cells in vitro (IC50 = 28-63 nM) and inhibits melanoma xenograph tumor growth in vivo (10-30 mg/kg) binds to tubulin (Ki = 3.4 &muM) and prevents tubulin

An aryl-benzoyl-imidazole which prevents proliferation of multidrug resistant cancer cells in vitro (IC50 = 28-63 nM) and inhibits melanoma xenograph tumor growth in vivo (10-30 mg/kg) binds to tubulin (Ki = 3.4 &muM) and prevents tubulin

An aryl-benzoyl-imidazole which prevents proliferation of multidrug resistant cancer cells in vitro (IC50 = 28-63 nM) and inhibits melanoma xenograph tumor growth in vivo (10-30 mg/kg) binds to tubulin (Ki = 3.4 &muM) and prevents tubulin

An intermediate used in the synthesis of potent DP2 receptor antagonists.