Biologically Active Small Molecules

An intermediate used in the synthesis of potent DP2 receptor antagonists.

An intermediate used in the synthesis of potent DP2 receptor antagonists.

A thiazolinone compound that directly inhibits 5-LO product formation in intact polymorphonuclear leukocytes and a soluble fraction of a S100 PMNL cell lysate (IC50s = 0.28 and 0.09 &muM, respectively).

A thiazolinone compound that directly inhibits 5-LO product formation in intact polymorphonuclear leukocytes and a soluble fraction of a S100 PMNL cell lysate (IC50s = 0.28 and 0.09 &muM, respectively).

A thiazolinone compound that directly inhibits 5-LO product formation in intact polymorphonuclear leukocytes and a soluble fraction of a S100 PMNL cell lysate (IC50s = 0.28 and 0.09 &muM, respectively).

A highly potent (IC50 = 12 nM) cPLA2&alpha inhibitor demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis.

A highly potent (IC50 = 12 nM) cPLA2&alpha inhibitor demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis.

A highly potent (IC50 = 12 nM) cPLA2&alpha inhibitor demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis.

A highly potent (IC50 = 12 nM) cPLA2&alpha inhibitor demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis.

A synthetic analog of natural AHLs that suppresses host immunity without inducing LasR inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC50 = 9.3 &muM) without concurrent cytotoxicity does not induce LasR at 100

A synthetic analog of natural AHLs that suppresses host immunity without inducing LasR inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC50 = 9.3 &muM) without concurrent cytotoxicity does not induce LasR at 100

A synthetic analog of natural AHLs that suppresses host immunity without inducing LasR inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC50 = 9.3 &muM) without concurrent cytotoxicity does not induce LasR at 100