Biologically Active Small Molecules

A synthetic analog of natural AHLs that suppresses host immunity without inducing LasR inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC50 = 9.3 &muM) without concurrent cytotoxicity does not induce LasR at 100

A thiophene carboximide derivative proposed to inhibit IKK2 likely to be useful in the treatment of inflammatory diseases and cancer.

A thiophene carboximide derivative proposed to inhibit IKK2 likely to be useful in the treatment of inflammatory diseases and cancer.

A thiophene carboximide derivative proposed to inhibit IKK2 likely to be useful in the treatment of inflammatory diseases and cancer.

A 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50 fold higher than required for the effect on cardiomyocytes, 1-5 &muM CAY10662

A 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50 fold higher than required for the effect on cardiomyocytes, 1-5 &muM CAY10662

A 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50 fold higher than required for the effect on cardiomyocytes, 1-5 &muM CAY10662

A 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50 fold higher than required for the effect on cardiomyocytes, 1-5 &muM CAY10662

A bioisostere of 17,18-EET which is approximately 50% more effective at reducing arrhythmic contraction frequency, without affecting amplitude, when tested at 30 nM.

A bioisostere of 17,18-EET which is approximately 50% more effective at reducing arrhythmic contraction frequency, without affecting amplitude, when tested at 30 nM.

A bioisostere of 17,18-EET which is approximately 50% more effective at reducing arrhythmic contraction frequency, without affecting amplitude, when tested at 30 nM.

A bioisostere of 17,18-EET which is approximately 50% more effective at reducing arrhythmic contraction frequency, without affecting amplitude, when tested at 30 nM.