Biologically Active Small Molecules

An inhibitor of the HAT PCAF (p300/CREB-binding protein-associated factor IC50 = 662 &muM), displaying a 2-fold improvement in inhibitory potency over anacardic acid dose dependently inhibits histone H4 acetylation in HepG2 cells in vitro at

An inhibitor of the HAT PCAF (p300/CREB-binding protein-associated factor IC50 = 662 &muM), displaying a 2-fold improvement in inhibitory potency over anacardic acid dose dependently inhibits histone H4 acetylation in HepG2 cells in vitro at

An inhibitor of the HAT PCAF (p300/CREB-binding protein-associated factor IC50 = 662 &muM), displaying a 2-fold improvement in inhibitory potency over anacardic acid dose dependently inhibits histone H4 acetylation in HepG2 cells in vitro at

A cysmethynil analog that inhibits Icmt with an IC₅₀ value of 0.86 &muM demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells (IC₅₀s = 2.

A cysmethynil analog that inhibits Icmt with an IC₅₀ value of 0.86 &muM demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells (IC₅₀s = 2.

A cysmethynil analog that inhibits Icmt with an IC₅₀ value of 0.86 &muM demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells (IC₅₀s = 2.

A benzoimidazole that potently inhibits human and rat recombinant mPGES-1 (IC₅₀ = 0.09 and 0.

A benzoimidazole that potently inhibits human and rat recombinant mPGES-1 (IC₅₀ = 0.09 and 0.

A benzoimidazole that potently inhibits human and rat recombinant mPGES-1 (IC₅₀ = 0.09 and 0.

An anionic oligopeptide-based bola-amphiphile that contains a hexane moiety flanked by a glycylglycine group at each end, which creates distinct hydrophilic and hydrophobic regions.

An anionic oligopeptide-based bola-amphiphile that contains a hexane moiety flanked by a glycylglycine group at each end, which creates distinct hydrophilic and hydrophobic regions.

An anionic oligopeptide-based bola-amphiphile that contains a hexane moiety flanked by a glycylglycine group at each end, which creates distinct hydrophilic and hydrophobic regions.