Biologically Active Small Molecules

An anionic oligopeptide-based bola-amphiphile that contains a hexane moiety flanked by a glycylglycine group at each end, which creates distinct hydrophilic and hydrophobic regions.

A benzothiazinone compound that selectively inhibits both MAO-B activity (IC₅₀ = 34.9 nM in human) and adenosine A2A receptors (Ki = 39.

A benzothiazinone compound that selectively inhibits both MAO-B activity (IC₅₀ = 34.9 nM in human) and adenosine A2A receptors (Ki = 39.

A benzothiazinone compound that selectively inhibits both MAO-B activity (IC₅₀ = 34.9 nM in human) and adenosine A2A receptors (Ki = 39.

A benzothiazinone compound that selectively inhibits both MAO-B activity (IC₅₀ = 34.9 nM in human) and adenosine A2A receptors (Ki = 39.

A dual modulator of p53-MDM2 interaction and NF-&kappaB signaling binds MDM2 (Ki = 250 nM), reducing MDM2-mediated turnover of p53 inhibits phosphorylation of I&kappaB&alpha and dose-dependently reduces nuclear accumulation of p65 inhibits

A dual modulator of p53-MDM2 interaction and NF-&kappaB signaling binds MDM2 (Ki = 250 nM), reducing MDM2-mediated turnover of p53 inhibits phosphorylation of I&kappaB&alpha and dose-dependently reduces nuclear accumulation of p65 inhibits

A dual modulator of p53-MDM2 interaction and NF-&kappaB signaling binds MDM2 (Ki = 250 nM), reducing MDM2-mediated turnover of p53 inhibits phosphorylation of I&kappaB&alpha and dose-dependently reduces nuclear accumulation of p65 inhibits

A dual modulator of p53-MDM2 interaction and NF-&kappaB signaling binds MDM2 (Ki = 250 nM), reducing MDM2-mediated turnover of p53 inhibits phosphorylation of I&kappaB&alpha and dose-dependently reduces nuclear accumulation of p65 inhibits

Inhibits the p53-Mdm2 interaction (Ki = 83 nM) and also dose-dependently reduces activation of the NF-&kappaB pathway prevents phosphorylation of I&kappaB&alpha by IKK&alpha, IKK&beta, and IKKE (IC₅₀s = 80.5, 78.

Inhibits the p53-Mdm2 interaction (Ki = 83 nM) and also dose-dependently reduces activation of the NF-&kappaB pathway prevents phosphorylation of I&kappaB&alpha by IKK&alpha, IKK&beta, and IKKE (IC₅₀s = 80.5, 78.

Inhibits the p53-Mdm2 interaction (Ki = 83 nM) and also dose-dependently reduces activation of the NF-&kappaB pathway prevents phosphorylation of I&kappaB&alpha by IKK&alpha, IKK&beta, and IKKE (IC₅₀s = 80.5, 78.