Biologically Active Small Molecules

An inhibitor of PHGDH, inhibiting serine synthesis from 3-PG in cells (IC₅₀ = 33 &microM) inhibits the proliferation of cancer cells by blocking de novo serine synthesis.

An inhibitor of PHGDH, inhibiting serine synthesis from 3-PG in cells (IC₅₀ = 33 &microM) inhibits the proliferation of cancer cells by blocking de novo serine synthesis.

An inhibitor of PHGDH, inhibiting serine synthesis from 3-PG in cells (IC₅₀ = 33 &microM) inhibits the proliferation of cancer cells by blocking de novo serine synthesis.

CC-115 is a potent dual inhibitor of mTOR and DNA-PK (IC₅₀s = 22 and 15 nM, respectively). CC-115 reduces PC3 cancer cell growth in vitro (IC₅₀ = 138 nM) and exhibits effective reduction of murine PC3 tumor xenografts

CC-115 is a potent dual inhibitor of mTOR and DNA-PK (IC₅₀s = 22 and 15 nM, respectively). CC-115 reduces PC3 cancer cell growth in vitro (IC₅₀ = 138 nM) and exhibits effective reduction of murine PC3 tumor xenografts

CC-115 is a potent dual inhibitor of mTOR and DNA-PK (IC₅₀s = 22 and 15 nM, respectively). CC-115 reduces PC3 cancer cell growth in vitro (IC₅₀ = 138 nM) and exhibits effective reduction of murine PC3 tumor xenografts

CC-115 is a potent dual inhibitor of mTOR and DNA-PK (IC₅₀s = 22 and 15 nM, respectively). CC-115 reduces PC3 cancer cell growth in vitro (IC₅₀ = 138 nM) and exhibits effective reduction of murine PC3 tumor xenografts

A potent, selective inhibitor of mTOR.

A potent, selective inhibitor of mTOR.

A potent, selective inhibitor of mTOR.

A potent, selective inhibitor of mTOR.

A potent, selective inhibitor of all three JNK isoforms (Ki values range from 25 to 50 nM) bioavailable when delivered by gavage, blocking JNK signaling and renal fibrosis in a rat obstructed kidney model decreases hepatic necrosis and apoptosis