Biologically Active Small Molecules

A potent, selective inhibitor of all three JNK isoforms (Ki values range from 25 to 50 nM) bioavailable when delivered by gavage, blocking JNK signaling and renal fibrosis in a rat obstructed kidney model decreases hepatic necrosis and apoptosis

A potent, selective inhibitor of all three JNK isoforms (Ki values range from 25 to 50 nM) bioavailable when delivered by gavage, blocking JNK signaling and renal fibrosis in a rat obstructed kidney model decreases hepatic necrosis and apoptosis

Inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC3 prostate cancer cells with an IC50 value of 9.8 &microM.

Inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC3 prostate cancer cells with an IC50 value of 9.8 &microM.

Inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC3 prostate cancer cells with an IC50 value of 9.8 &microM.

Inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC3 prostate cancer cells with an IC50 value of 9.8 &microM.

A novel, specific inhibitor of Rho pathway-mediated signaling and activation of SRF transcription inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations.

A novel, specific inhibitor of Rho pathway-mediated signaling and activation of SRF transcription inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations.

A novel, specific inhibitor of Rho pathway-mediated signaling and activation of SRF transcription inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations.

A novel, specific inhibitor of Rho pathway-mediated signaling and activation of SRF transcription inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines at nanomolar to low micromolar concentrations.

An inhibitor of SRE activation in PC3 cells (IC₅₀ = 6.4 &muM), with 87% inhibition of SRE activation achieved at 100 &muM inhibits PC3 cell migration (IC₅₀ = 4.

An inhibitor of SRE activation in PC3 cells (IC₅₀ = 6.4 &muM), with 87% inhibition of SRE activation achieved at 100 &muM inhibits PC3 cell migration (IC₅₀ = 4.