Biologically Active Small Molecules

A potent inhibitor of Aurora kinases (IC₅₀s = 15, 25 and 19 nM for Aurora A, B, and C, respectively) also inhibits FLT3 as well as the constitutively active FLT3-ITD form (IC₅₀s = 1.2 and 4.

A potent inhibitor of Aurora kinases (IC₅₀s = 15, 25 and 19 nM for Aurora A, B, and C, respectively) also inhibits FLT3 as well as the constitutively active FLT3-ITD form (IC₅₀s = 1.2 and 4.

A potent inhibitor of Aurora kinases (IC₅₀s = 15, 25 and 19 nM for Aurora A, B, and C, respectively) also inhibits FLT3 as well as the constitutively active FLT3-ITD form (IC₅₀s = 1.2 and 4.

CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC₅₀= 5 nM). It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19.

CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC₅₀= 5 nM). It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19.

CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC₅₀= 5 nM). It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19.

A fluorescent molecular rotor characterized by low background fluorescence, low fluorescence anisotropy, and good water solubility its large hydrophobic structures allow it to associate in a non-covalent manner with hydrophobic pockets in proteins

A fluorescent molecular rotor characterized by low background fluorescence, low fluorescence anisotropy, and good water solubility its large hydrophobic structures allow it to associate in a non-covalent manner with hydrophobic pockets in proteins

A fluorescent molecular rotor characterized by low background fluorescence, low fluorescence anisotropy, and good water solubility its large hydrophobic structures allow it to associate in a non-covalent manner with hydrophobic pockets in proteins

A selective RAR&gamma agonist (Kds = 150, 1,500, and 2,750 nM for RAR&gamma, RAR&beta, and RAR&alpha receptors, respectively) demonstrates transcriptional activity at RAR&gamma with an AC₅₀ value of 1.8 nM.

A selective RAR&gamma agonist (Kds = 150, 1,500, and 2,750 nM for RAR&gamma, RAR&beta, and RAR&alpha receptors, respectively) demonstrates transcriptional activity at RAR&gamma with an AC₅₀ value of 1.8 nM.

A selective RAR&gamma agonist (Kds = 150, 1,500, and 2,750 nM for RAR&gamma, RAR&beta, and RAR&alpha receptors, respectively) demonstrates transcriptional activity at RAR&gamma with an AC₅₀ value of 1.8 nM.