Biologically Active Small Molecules

A synthetic oleanane triterpenoid that blocks iNOS and COX-2 synthesis in INF-&gamma-activated mouse macrophages (IC₅₀ = 0.4 nM) inhibits proliferation and induces apoptosis in various cancer cell lines and upregulates genes involved in

A synthetic oleanane triterpenoid that blocks iNOS and COX-2 synthesis in INF-&gamma-activated mouse macrophages (IC₅₀ = 0.4 nM) inhibits proliferation and induces apoptosis in various cancer cell lines and upregulates genes involved in

A trifluoroethylamide derivative of CDDO that enhances Nrf2 expression and signaling in various models of neurodegeneration demonstrates anticancer activity against several neuroblastoma cell lines with IC₅₀s = 85-170 nM.

A trifluoroethylamide derivative of CDDO that enhances Nrf2 expression and signaling in various models of neurodegeneration demonstrates anticancer activity against several neuroblastoma cell lines with IC₅₀s = 85-170 nM.

A trifluoroethylamide derivative of CDDO that enhances Nrf2 expression and signaling in various models of neurodegeneration demonstrates anticancer activity against several neuroblastoma cell lines with IC₅₀s = 85-170 nM.

A cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC₅₀s = 0.6 and 0.5 nM, respectively) blocks the growth of several cancer cell lines (IC₅₀ values range from 20 to 92 nM).

A cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC₅₀s = 0.6 and 0.5 nM, respectively) blocks the growth of several cancer cell lines (IC₅₀ values range from 20 to 92 nM).

A cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC₅₀s = 0.6 and 0.5 nM, respectively) blocks the growth of several cancer cell lines (IC₅₀ values range from 20 to 92 nM).

Inhibitor of Cdk1/cyclin B and Cdk/p25 (IC₅₀s = 600 and 400 nM, respectively).

Inhibitor of Cdk1/cyclin B and Cdk/p25 (IC₅₀s = 600 and 400 nM, respectively).

Inhibitor of Cdk1/cyclin B and Cdk/p25 (IC₅₀s = 600 and 400 nM, respectively).

A 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 (IC₅₀ = 60 nM).