Biologically Active Small Molecules

A thiazolidinone that selectively blocks the CFTR channel (Ki = 300 nM) in a voltage-independent manner prevents cholera toxin-induced fluid secretion in the small intestine, when given by intraperitoneal injection can affect intracellular GSH

A thiazolidinone that selectively blocks the CFTR channel (Ki = 300 nM) in a voltage-independent manner prevents cholera toxin-induced fluid secretion in the small intestine, when given by intraperitoneal injection can affect intracellular GSH

A stable carbacyclic PGI2 analog of that inhibits ADP-induced platelet aggregation 25% at a concentration of 50 nM10 mg/kg (oral) or 1 mg/kg (intraduodenal) prevents thrombotic arterial occlusion.

A stable carbacyclic PGI2 analog of that inhibits ADP-induced platelet aggregation 25% at a concentration of 50 nM10 mg/kg (oral) or 1 mg/kg (intraduodenal) prevents thrombotic arterial occlusion.

A stable carbacyclic PGI2 analog of that inhibits ADP-induced platelet aggregation 25% at a concentration of 50 nM10 mg/kg (oral) or 1 mg/kg (intraduodenal) prevents thrombotic arterial occlusion.

A potent, selective inhibitor of BTK (IC₅₀ = 1.9 nM) prevents BCR-mediated B lymphocyte proliferation reduces cytokine levels within joints and ameliorates symptoms in a mouse model of autoantibody-induced arthritis.

A potent, selective inhibitor of BTK (IC₅₀ = 1.9 nM) prevents BCR-mediated B lymphocyte proliferation reduces cytokine levels within joints and ameliorates symptoms in a mouse model of autoantibody-induced arthritis.

A potent, selective inhibitor of BTK (IC₅₀ = 1.9 nM) prevents BCR-mediated B lymphocyte proliferation reduces cytokine levels within joints and ameliorates symptoms in a mouse model of autoantibody-induced arthritis.

A potent, selective inhibitor of BTK (IC₅₀ = 1.9 nM) prevents BCR-mediated B lymphocyte proliferation reduces cytokine levels within joints and ameliorates symptoms in a mouse model of autoantibody-induced arthritis.

An inhibitor of ATR and ATM kinases (IC₅₀ = ~ 200 nM) that induces cell death in prematurely senescent breast, lung, and colon cancer cells.

An inhibitor of ATR and ATM kinases (IC₅₀ = ~ 200 nM) that induces cell death in prematurely senescent breast, lung, and colon cancer cells.

An inhibitor of ATR and ATM kinases (IC₅₀ = ~ 200 nM) that induces cell death in prematurely senescent breast, lung, and colon cancer cells.