-
Add to Cart The item has been added13322-25A selective inhibitor of MNK1 in vitro (IC<sub>50</sub> = 2.2 &muM), with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases blocks the phosphorylation of eIF4E in response to TNF-&alpha, arsenite, anisomycin, PMA, or -
Add to Cart The item has been added13322-5A selective inhibitor of MNK1 in vitro (IC<sub>50</sub> = 2.2 &muM), with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases blocks the phosphorylation of eIF4E in response to TNF-&alpha, arsenite, anisomycin, PMA, or -
Add to Cart The item has been added17126-1A potent, selective agonist of the adenosine A2A receptor (Ki = 11-46 nM) less effective at adenosine A1 and A3 receptors (Kis = 0.5-3.1 and 0.6-1 µM, respectively) and is without effect at adenosine A2B (Ki > 10 µM). -
Add to Cart The item has been added17126-10A potent, selective agonist of the adenosine A2A receptor (Ki = 11-46 nM) less effective at adenosine A1 and A3 receptors (Kis = 0.5-3.1 and 0.6-1 µM, respectively) and is without effect at adenosine A2B (Ki > 10 µM). -
Add to Cart The item has been added17126-25A potent, selective agonist of the adenosine A2A receptor (Ki = 11-46 nM) less effective at adenosine A1 and A3 receptors (Kis = 0.5-3.1 and 0.6-1 µM, respectively) and is without effect at adenosine A2B (Ki > 10 µM). -
Add to Cart The item has been added17126-5A potent, selective agonist of the adenosine A2A receptor (Ki = 11-46 nM) less effective at adenosine A1 and A3 receptors (Kis = 0.5-3.1 and 0.6-1 µM, respectively) and is without effect at adenosine A2B (Ki > 10 µM). -
Add to Cart The item has been added16154-10A potent and specific antagonist of AhR that blocks activation by TCDD (IC<sub>50</sub> = 0.03 µM) prevents the induction of CYP1A1 by TCDD in HepG2 cells and in livers of mice suppresses Th17 cell differentiation both in vitro and in vivo. -
Add to Cart The item has been added16154-25A potent and specific antagonist of AhR that blocks activation by TCDD (IC<sub>50</sub> = 0.03 µM) prevents the induction of CYP1A1 by TCDD in HepG2 cells and in livers of mice suppresses Th17 cell differentiation both in vitro and in vivo. -
Add to Cart The item has been added16154-5A potent and specific antagonist of AhR that blocks activation by TCDD (IC<sub>50</sub> = 0.03 µM) prevents the induction of CYP1A1 by TCDD in HepG2 cells and in livers of mice suppresses Th17 cell differentiation both in vitro and in vivo. -
Add to Cart The item has been added16154-50A potent and specific antagonist of AhR that blocks activation by TCDD (IC<sub>50</sub> = 0.03 µM) prevents the induction of CYP1A1 by TCDD in HepG2 cells and in livers of mice suppresses Th17 cell differentiation both in vitro and in vivo. -
Add to Cart The item has been added18658-1A synthetic analog of retinoic acid that binds to retinoic acid receptors with similar efficiency as retinoic acid (Kis in the nM range) yet does not display affinity for cellular retinoic acid-binding protein (Ki = 540 µM). -
Add to Cart The item has been added18658-10A synthetic analog of retinoic acid that binds to retinoic acid receptors with similar efficiency as retinoic acid (Kis in the nM range) yet does not display affinity for cellular retinoic acid-binding protein (Ki = 540 µM).
