Biologically Active Small Molecules

A fungal mycotoxin that inhibits the Lys9-specific histone methyltransferases SU(VAR)3-9 (IC₅₀ = 0.8 &muM), G9a (IC₅₀ = 2.5 &muM), and DIM5 (IC₅₀= 3 &muM).

A mycotoxic cytochalasin that targets filamentous actin and demonstrates antibacterial and nematicidal effects as well as induces apoptosis in cancer cell lines.

A mycotoxic cytochalasin that targets filamentous actin and demonstrates antibacterial and nematicidal effects as well as induces apoptosis in cancer cell lines.

Chalcone is an enone on which a variety of structures are based. Chalcone derivatives typically exhibit anti-inflammatory, antioxidative, neuroprotective, analgesic, anticancer, and anti-parasitic activities.

Chalcone is an enone on which a variety of structures are based. Chalcone derivatives typically exhibit anti-inflammatory, antioxidative, neuroprotective, analgesic, anticancer, and anti-parasitic activities.

Chalcone is an enone on which a variety of structures are based. Chalcone derivatives typically exhibit anti-inflammatory, antioxidative, neuroprotective, analgesic, anticancer, and anti-parasitic activities.

A potent, cell permeable inhibitor of PKC (IC50 = 660 nM) also inhibits BclXL function (IC50 = 1.5 &muM), inducing apoptosis in several cancer cell lines can have PKC-independent effects, activate p38 and JUNK signaling pathways, and induce

A potent, cell permeable inhibitor of PKC (IC50 = 660 nM) also inhibits BclXL function (IC50 = 1.5 &muM), inducing apoptosis in several cancer cell lines can have PKC-independent effects, activate p38 and JUNK signaling pathways, and induce

A potent, cell permeable inhibitor of PKC (IC50 = 660 nM) also inhibits BclXL function (IC50 = 1.5 &muM), inducing apoptosis in several cancer cell lines can have PKC-independent effects, activate p38 and JUNK signaling pathways, and induce

A bile acid and FXR ligand (EC50 = 13-34 &muM) that is a key regulator of cholesterol homeostasis exhibits toxicity that is linked to increased glutathione and increased oxidative stress excess CDCA contributes to liver and intestinal cancers.

A bile acid and FXR ligand (EC50 = 13-34 &muM) that is a key regulator of cholesterol homeostasis exhibits toxicity that is linked to increased glutathione and increased oxidative stress excess CDCA contributes to liver and intestinal cancers.

A bile acid and FXR ligand (EC50 = 13-34 &muM) that is a key regulator of cholesterol homeostasis exhibits toxicity that is linked to increased glutathione and increased oxidative stress excess CDCA contributes to liver and intestinal cancers.