Biologically Active Small Molecules

AZD-7762 is an inhibitor of checkpoint kinase 1 (Chk1) that increases sensitivity to DNA-damaging compounds. AZD-7762 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for a variety of cancers.

A selective, ATP-competitive inhibitor of the DNA damage control kinase, Chk2 (IC₅₀ = 15 nM) prevents apoptosis in human T-cells exposed to ionizing radiation (EC₅₀ = 3-7.6 &microM).

A selective, ATP-competitive inhibitor of the DNA damage control kinase, Chk2 (IC₅₀ = 15 nM) prevents apoptosis in human T-cells exposed to ionizing radiation (EC₅₀ = 3-7.6 &microM).

A selective, ATP-competitive inhibitor of the DNA damage control kinase, Chk2 (IC₅₀ = 15 nM) prevents apoptosis in human T-cells exposed to ionizing radiation (EC₅₀ = 3-7.6 &microM).

A histamine H1 receptor antagonist (Ki = 9 nM) that is effective against HCV (EC₅₀ = 44 nM), preventing viral entry into host cells.

A histamine H1 receptor antagonist (Ki = 9 nM) that is effective against HCV (EC₅₀ = 44 nM), preventing viral entry into host cells.

A histamine H1 receptor antagonist (Ki = 9 nM) that is effective against HCV (EC₅₀ = 44 nM), preventing viral entry into host cells.

A histamine H1 receptor antagonist (Ki = 9 nM) that is effective against HCV (EC₅₀ = 44 nM), preventing viral entry into host cells.

An an antimicrobial agent that is often used in antiseptics and dental products such as toothpaste and mouthwash inhibits MMP-2, -8, and -9.

An an antimicrobial agent that is often used in antiseptics and dental products such as toothpaste and mouthwash inhibits MMP-2, -8, and -9.

An an antimicrobial agent that is often used in antiseptics and dental products such as toothpaste and mouthwash inhibits MMP-2, -8, and -9.

An an antimicrobial agent that is often used in antiseptics and dental products such as toothpaste and mouthwash inhibits MMP-2, -8, and -9.