Biologically Active Small Molecules

A thiazide diuretic that increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.

A thiazide diuretic that increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.

A thiazide diuretic that increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.

A macrolide-type antibiotic that inhibits pyruvate carboxylases from Bacillus, Azotobacter, rat, and chicken (Ki or IC₅₀ = 173, 500, 260, and 120 &muM, respectively) also inhibits MDH1 (cytoplasmic) and MDH2 (mitochondrial)

A macrolide-type antibiotic that inhibits pyruvate carboxylases from Bacillus, Azotobacter, rat, and chicken (Ki or IC₅₀ = 173, 500, 260, and 120 &muM, respectively) also inhibits MDH1 (cytoplasmic) and MDH2 (mitochondrial)

A phenothiazine classified as an antipsychotic compound antagonizes dopamine and serotonin receptors (Kis = 0.66, 0.

A phenothiazine classified as an antipsychotic compound antagonizes dopamine and serotonin receptors (Kis = 0.66, 0.

A phenothiazine classified as an antipsychotic compound antagonizes dopamine and serotonin receptors (Kis = 0.66, 0.

A phenothiazine classified as an antipsychotic compound antagonizes dopamine and serotonin receptors (Kis = 0.66, 0.

A nonthiazide diuretic that inhibits the sodium/chloride cotransporter in the distal convoluted tubule of the kidney also effectively inhibits the activity of most platelet carbonic anhydrase isozymes (IC₅₀s = 2.8 nM - 11 &microM).

A nonthiazide diuretic that inhibits the sodium/chloride cotransporter in the distal convoluted tubule of the kidney also effectively inhibits the activity of most platelet carbonic anhydrase isozymes (IC₅₀s = 2.8 nM - 11 &microM).

A nonthiazide diuretic that inhibits the sodium/chloride cotransporter in the distal convoluted tubule of the kidney also effectively inhibits the activity of most platelet carbonic anhydrase isozymes (IC₅₀s = 2.8 nM - 11 &microM).