Biologically Active Small Molecules

A potent inhibitor of MEK in (IC50 = 2.3 nM Kd = 74 nM when activated with ATP) that suppresses phosphorylation of ERK in mouse colon 26 tumors (IC50 = 35 nM).

A potent inhibitor of MEK in (IC50 = 2.3 nM Kd = 74 nM when activated with ATP) that suppresses phosphorylation of ERK in mouse colon 26 tumors (IC50 = 35 nM).

A potent, selective, orally bioavailable inhibitor of ACAT-1 (IC₅₀ = 73 nM).

A potent, selective, orally bioavailable inhibitor of ACAT-1 (IC₅₀ = 73 nM).

A potent, selective, orally bioavailable inhibitor of ACAT-1 (IC₅₀ = 73 nM).

A potent, selective, orally bioavailable inhibitor of ACAT-1 (IC₅₀ = 73 nM).

An inhibitor of class I HDACs with IC50 values of 0.9, 0.

An inhibitor of class I HDACs with IC50 values of 0.9, 0.

An inhibitor of class I HDACs with IC50 values of 0.9, 0.

A prostacyclin analog that is orally active with prolonged availability in vivo, having a terminal half-life in plasma of one hour inhibits the pro-inflammatory actions of certain leukocytes, suppresses cardiac fibrosis, and blocks mitogenesis of

A prostacyclin analog that is orally active with prolonged availability in vivo, having a terminal half-life in plasma of one hour inhibits the pro-inflammatory actions of certain leukocytes, suppresses cardiac fibrosis, and blocks mitogenesis of

A prostacyclin analog that is orally active with prolonged availability in vivo, having a terminal half-life in plasma of one hour inhibits the pro-inflammatory actions of certain leukocytes, suppresses cardiac fibrosis, and blocks mitogenesis of