Biologically Active Small Molecules

A platinum-containing compound that acts as an alkylating agent used alone or in combination therapy in the treatment of several types of cancer inhibits the RecA recombinase of M. tuberculosis (IC₅₀ = 2 &microM), blocking protein

A SSRI which is commonly prescribed as an antidepressant also acts as an antagonist of nicotinic acetylcholine receptors (IC₅₀= 0.93 &microM).

A SSRI which is commonly prescribed as an antidepressant also acts as an antagonist of nicotinic acetylcholine receptors (IC₅₀= 0.93 &microM).

A SSRI which is commonly prescribed as an antidepressant also acts as an antagonist of nicotinic acetylcholine receptors (IC₅₀= 0.93 &microM).

An agonist of human CAR (EC₅₀ = 49 nM) induces nuclear translocation of human CAR in hepatocytes, followed by increased expression of CAR-regulated genes.

An agonist of human CAR (EC₅₀ = 49 nM) induces nuclear translocation of human CAR in hepatocytes, followed by increased expression of CAR-regulated genes.

An agonist of human CAR (EC₅₀ = 49 nM) induces nuclear translocation of human CAR in hepatocytes, followed by increased expression of CAR-regulated genes.

An endogenous intermediate in the synthesis of phosphatidylcholine that demonstrates protective effects in cerebral ischemia, traumatic brain injury, and memory disorders when administered exogenously.

An endogenous intermediate in the synthesis of phosphatidylcholine that demonstrates protective effects in cerebral ischemia, traumatic brain injury, and memory disorders when administered exogenously.

An endogenous intermediate in the synthesis of phosphatidylcholine that demonstrates protective effects in cerebral ischemia, traumatic brain injury, and memory disorders when administered exogenously.

An endogenous intermediate in the synthesis of phosphatidylcholine that demonstrates protective effects in cerebral ischemia, traumatic brain injury, and memory disorders when administered exogenously.

A mycotoxin that inhibits the mitochondrial ATP synthetase system inhibits soluble ATPase (KD = 4.1 &microM), ADP-stimulated respiration in isolated rat liver mitochondria (KD = 0.