Biologically Active Small Molecules

A mycotoxin that inhibits the mitochondrial ATP synthetase system inhibits soluble ATPase (KD = 4.1 &microM), ADP-stimulated respiration in isolated rat liver mitochondria (KD = 0.

A mycotoxin found as food contaminants that causes mycotoxic nephropathy in livestock and Balkan nephropathy and yellow rice fever in humans induces apoptosis, blocks tubulin polymerization, and disrupts mitotic spindle assembly.

A mycotoxin found as food contaminants that causes mycotoxic nephropathy in livestock and Balkan nephropathy and yellow rice fever in humans induces apoptosis, blocks tubulin polymerization, and disrupts mitotic spindle assembly.

A mycotoxin found as food contaminants that causes mycotoxic nephropathy in livestock and Balkan nephropathy and yellow rice fever in humans induces apoptosis, blocks tubulin polymerization, and disrupts mitotic spindle assembly.

A highly sensitive, rhodamine phenylglyoxal-based fluorophore that specifically detects protein citrullination via a chemoselective reaction between glyoxal and citrulline reacts with any citrulline-containing protein and can be analyzed with

A highly sensitive, rhodamine phenylglyoxal-based fluorophore that specifically detects protein citrullination via a chemoselective reaction between glyoxal and citrulline reacts with any citrulline-containing protein and can be analyzed with

A highly sensitive, rhodamine phenylglyoxal-based fluorophore that specifically detects protein citrullination via a chemoselective reaction between glyoxal and citrulline reacts with any citrulline-containing protein and can be analyzed with

A potent and selective antagonist of the EP4 receptor (Ki = 13 and 20 nM for human and rat EP4, respectively) inhibits PGE2-evoked elevation in intracellular cAMP in cells and, in vivo, reduces thermal hyperalgesia induced by intraplantar injection

A potent and selective antagonist of the EP4 receptor (Ki = 13 and 20 nM for human and rat EP4, respectively) inhibits PGE2-evoked elevation in intracellular cAMP in cells and, in vivo, reduces thermal hyperalgesia induced by intraplantar injection

A potent and selective antagonist of the EP4 receptor (Ki = 13 and 20 nM for human and rat EP4, respectively) inhibits PGE2-evoked elevation in intracellular cAMP in cells and, in vivo, reduces thermal hyperalgesia induced by intraplantar injection

A potent and selective antagonist of the EP4 receptor (Ki = 13 and 20 nM for human and rat EP4, respectively) inhibits PGE2-evoked elevation in intracellular cAMP in cells and, in vivo, reduces thermal hyperalgesia induced by intraplantar injection

A selective antagonist of EP4 (Ki = 3.2 nM) that less potently binds EP2 (Ki = 630 nM) and has no affinity for EP1 or EP3 delays the healing of gastric ulcers, suppressing the upregulation of VEGF expression and angiogenesis blocks pain and