Biologically Active Small Molecules

A selective antagonist of EP4 (Ki = 3.2 nM) that less potently binds EP2 (Ki = 630 nM) and has no affinity for EP1 or EP3 delays the healing of gastric ulcers, suppressing the upregulation of VEGF expression and angiogenesis blocks pain and

A selective antagonist of EP4 (Ki = 3.2 nM) that less potently binds EP2 (Ki = 630 nM) and has no affinity for EP1 or EP3 delays the healing of gastric ulcers, suppressing the upregulation of VEGF expression and angiogenesis blocks pain and

A selective antagonist of EP4 (Ki = 3.2 nM) that less potently binds EP2 (Ki = 630 nM) and has no affinity for EP1 or EP3 delays the healing of gastric ulcers, suppressing the upregulation of VEGF expression and angiogenesis blocks pain and

A cell-permeable inhibitor of Arp2/3 complex action that inhibits actin polymerization in vitro, using human, bovine and fission yeast proteins (IC₅₀s = 4, 32, and 24 &microM, respectively) prevents the formation of actin filament comet

A cell-permeable inhibitor of Arp2/3 complex action that inhibits actin polymerization in vitro, using human, bovine and fission yeast proteins (IC₅₀s = 4, 32, and 24 &microM, respectively) prevents the formation of actin filament comet

A cell-permeable inhibitor of Arp2/3 complex action that inhibits actin polymerization in vitro, using human, bovine and fission yeast proteins (IC₅₀s = 4, 32, and 24 &microM, respectively) prevents the formation of actin filament comet

A &beta3-adrenoceptor agonist (EC₅₀ = 3 nM) that is &gt10,000-fold selective over &beta1 and &beta2 causes a rapid decrease in blood glucose level in mice and has been used to study the induction of brown adipocytes and to increase

A &beta3-adrenoceptor agonist (EC₅₀ = 3 nM) that is &gt10,000-fold selective over &beta1 and &beta2 causes a rapid decrease in blood glucose level in mice and has been used to study the induction of brown adipocytes and to increase

A &beta3-adrenoceptor agonist (EC₅₀ = 3 nM) that is &gt10,000-fold selective over &beta1 and &beta2 causes a rapid decrease in blood glucose level in mice and has been used to study the induction of brown adipocytes and to increase

A &beta3-adrenoceptor agonist (EC₅₀ = 3 nM) that is &gt10,000-fold selective over &beta1 and &beta2 causes a rapid decrease in blood glucose level in mice and has been used to study the induction of brown adipocytes and to increase

A potent, irreversible inhibitor of EGFR kinase activity (IC₅₀ = 370 pM) halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC₅₀s = 31-125 nM) profoundly blocks the growth of EGFR-overexpressing tumors in nude mice

A potent, irreversible inhibitor of EGFR kinase activity (IC₅₀ = 370 pM) halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC₅₀s = 31-125 nM) profoundly blocks the growth of EGFR-overexpressing tumors in nude mice