Biologically Active Small Molecules

A potent, irreversible inhibitor of EGFR kinase activity (IC₅₀ = 370 pM) halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC₅₀s = 31-125 nM) profoundly blocks the growth of EGFR-overexpressing tumors in nude mice

A selective inhibitor of human collagenase-3, also known as MMP-13, producing 89% inhibition at 10 &microg/ml used to evaluate the role of MMP-13 in diverse processes.

A selective inhibitor of human collagenase-3, also known as MMP-13, producing 89% inhibition at 10 &microg/ml used to evaluate the role of MMP-13 in diverse processes.

A selective inhibitor of human collagenase-3, also known as MMP-13, producing 89% inhibition at 10 &microg/ml used to evaluate the role of MMP-13 in diverse processes.

A selective inhibitor of human collagenase-3, also known as MMP-13, producing 89% inhibition at 10 &microg/ml used to evaluate the role of MMP-13 in diverse processes.

An inhibitor of PAD4 deimination activity (IC50 = 5.9 &muM) that also inhibits PAD1 and PAD3 (IC50 = 0.

An inhibitor of PAD4 deimination activity (IC50 = 5.9 &muM) that also inhibits PAD1 and PAD3 (IC50 = 0.

An inhibitor of PAD4 deimination activity (IC50 = 5.9 &muM) that also inhibits PAD1 and PAD3 (IC50 = 0.

An adenosine analog which shows selective cytotoxicity against both proliferating and non-dividing lymphocytes inhibits lymphocyte growth with an IC₅₀ value of 45 nM.

An adenosine analog which shows selective cytotoxicity against both proliferating and non-dividing lymphocytes inhibits lymphocyte growth with an IC₅₀ value of 45 nM.

An adenosine analog which shows selective cytotoxicity against both proliferating and non-dividing lymphocytes inhibits lymphocyte growth with an IC₅₀ value of 45 nM.

A macrolide antibiotic with effectiveness against pneumococci, Streptococcus, Listeria, Corynebacterium, and Helicobacter.