Biologically Active Small Molecules

A macrolide antibiotic with effectiveness against pneumococci, Streptococcus, Listeria, Corynebacterium, and Helicobacter.

A macrolide antibiotic with effectiveness against pneumococci, Streptococcus, Listeria, Corynebacterium, and Helicobacter.

A &beta-lactamase inhibitor that is effective against Ambler class A &beta-lactamases (IC₅₀ values range from 12 to 60 nM) commonly used with other antibiotics that would be inactivated by &beta-lactamases.

A &beta-lactamase inhibitor that is effective against Ambler class A &beta-lactamases (IC₅₀ values range from 12 to 60 nM) commonly used with other antibiotics that would be inactivated by &beta-lactamases.

A &beta-lactamase inhibitor that is effective against Ambler class A &beta-lactamases (IC₅₀ values range from 12 to 60 nM) commonly used with other antibiotics that would be inactivated by &beta-lactamases.

A &beta-lactamase inhibitor that is effective against Ambler class A &beta-lactamases (IC₅₀ values range from 12 to 60 nM) commonly used with other antibiotics that would be inactivated by &beta-lactamases.

A selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity to muscarinic receptors (Ki = 16 nM) and is a positive allosteric modulator of P2X7 receptors inhibits histamine-induced bronchoconstriction in asthma and

A selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity to muscarinic receptors (Ki = 16 nM) and is a positive allosteric modulator of P2X7 receptors inhibits histamine-induced bronchoconstriction in asthma and

A selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity to muscarinic receptors (Ki = 16 nM) and is a positive allosteric modulator of P2X7 receptors inhibits histamine-induced bronchoconstriction in asthma and

A selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity to muscarinic receptors (Ki = 16 nM) and is a positive allosteric modulator of P2X7 receptors inhibits histamine-induced bronchoconstriction in asthma and

An antihistamine that antagonizes the H1 receptor at high nanomolar concentrations less potently blocks TRPC5 (IC₅₀ = 1.0-1.3 &microM), with at least 6-fold selectivity for TRPC5 over other TRP channels.

An antihistamine that antagonizes the H1 receptor at high nanomolar concentrations less potently blocks TRPC5 (IC₅₀ = 1.0-1.3 &microM), with at least 6-fold selectivity for TRPC5 over other TRP channels.