Biologically Active Small Molecules

An antihistamine that antagonizes the H1 receptor at high nanomolar concentrations less potently blocks TRPC5 (IC₅₀ = 1.0-1.3 &microM), with at least 6-fold selectivity for TRPC5 over other TRP channels.

An antihistamine that antagonizes the H1 receptor at high nanomolar concentrations less potently blocks TRPC5 (IC₅₀ = 1.0-1.3 &microM), with at least 6-fold selectivity for TRPC5 over other TRP channels.

A sympathomimetic &beta2-adrenoceptor agonist that relaxes bronchial smooth muscle and at higher doses acts as an anabolic steroid, promoting skeletal muscle protein synthesis.

A sympathomimetic &beta2-adrenoceptor agonist that relaxes bronchial smooth muscle and at higher doses acts as an anabolic steroid, promoting skeletal muscle protein synthesis.

A sympathomimetic &beta2-adrenoceptor agonist that relaxes bronchial smooth muscle and at higher doses acts as an anabolic steroid, promoting skeletal muscle protein synthesis.

A sympathomimetic &beta2-adrenoceptor agonist that relaxes bronchial smooth muscle and at higher doses acts as an anabolic steroid, promoting skeletal muscle protein synthesis.

A fluoroquinolone antibiotic that displays broad spectrum antibacterial activity by inhibiting the bacterial regulatory enzyme DNA gyrase (IC₅₀ = 0.92 &microg/ml) as well as topoisomerase IV (IC₅₀ = 1.62 &microg/ml).

A fluoroquinolone antibiotic that displays broad spectrum antibacterial activity by inhibiting the bacterial regulatory enzyme DNA gyrase (IC₅₀ = 0.92 &microg/ml) as well as topoisomerase IV (IC₅₀ = 1.62 &microg/ml).

A fluoroquinolone antibiotic that displays broad spectrum antibacterial activity by inhibiting the bacterial regulatory enzyme DNA gyrase (IC₅₀ = 0.92 &microg/ml) as well as topoisomerase IV (IC₅₀ = 1.62 &microg/ml).

A fluoroquinolone antibiotic that displays broad spectrum antibacterial activity by inhibiting the bacterial regulatory enzyme DNA gyrase (IC₅₀ = 0.92 &microg/ml) as well as topoisomerase IV (IC₅₀ = 1.62 &microg/ml).

An antibiotic which binds the bacterial 50S ribosomal subunit and interferes with protein synthesis effective against anaerobes and is commonly used against Gram positive bacteria.

An antibiotic which binds the bacterial 50S ribosomal subunit and interferes with protein synthesis effective against anaerobes and is commonly used against Gram positive bacteria.