Biologically Active Small Molecules

A potent MAO inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 &microM, respectively) also inhibits the sigma receptor &sigma1 on Jurkat human T lymphocyte cells (IC₅₀ = 31 nM).

An imidazole antifungal tightly binds sterol 14-&alpha demethylase isoform B from A. fumigatus (KD = 103 nM) and disturbs the fungal cell membrane inhibits the calcium-dependent potassium channels Kv1.

An imidazole antifungal tightly binds sterol 14-&alpha demethylase isoform B from A. fumigatus (KD = 103 nM) and disturbs the fungal cell membrane inhibits the calcium-dependent potassium channels Kv1.

An imidazole antifungal tightly binds sterol 14-&alpha demethylase isoform B from A. fumigatus (KD = 103 nM) and disturbs the fungal cell membrane inhibits the calcium-dependent potassium channels Kv1.

A major metabolite of clozapine used in designer receptor exclusively activated by designer drug, also known as DREADD, technology to modulate synthetic receptors in vivo.

A major metabolite of clozapine used in designer receptor exclusively activated by designer drug, also known as DREADD, technology to modulate synthetic receptors in vivo.

A major metabolite of clozapine used in designer receptor exclusively activated by designer drug, also known as DREADD, technology to modulate synthetic receptors in vivo.

A major metabolite of clozapine used in designer receptor exclusively activated by designer drug, also known as DREADD, technology to modulate synthetic receptors in vivo.

Acts as a partial agonist at the 5-HT1A receptor (pKi = 7) and interferes to a lesser extent with the binding of dopamine at D1, D2, D3 and D5 receptors, yet has a high affinity for the D4 receptor.

Acts as a partial agonist at the 5-HT1A receptor (pKi = 7) and interferes to a lesser extent with the binding of dopamine at D1, D2, D3 and D5 receptors, yet has a high affinity for the D4 receptor.

Acts as a partial agonist at the 5-HT1A receptor (pKi = 7) and interferes to a lesser extent with the binding of dopamine at D1, D2, D3 and D5 receptors, yet has a high affinity for the D4 receptor.

Acts as a partial agonist at the 5-HT1A receptor (pKi = 7) and interferes to a lesser extent with the binding of dopamine at D1, D2, D3 and D5 receptors, yet has a high affinity for the D4 receptor.