Biologically Active Small Molecules

An irreversible inhibitor of mutant forms of EGFR including T790M (Ki = 21.5 nM) with minimal activity at the wild-type EGFR (Ki = 303.

An irreversible inhibitor of mutant forms of EGFR including T790M (Ki = 21.5 nM) with minimal activity at the wild-type EGFR (Ki = 303.

A selective, orally available inhibitor of MEK1 (IC₅₀ = 4.2 nM) induces differentiation and apoptosis in cancer cells lines.

A selective, orally available inhibitor of MEK1 (IC₅₀ = 4.2 nM) induces differentiation and apoptosis in cancer cells lines.

A selective, orally available inhibitor of MEK1 (IC₅₀ = 4.2 nM) induces differentiation and apoptosis in cancer cells lines.

A selective, orally available inhibitor of MEK1 (IC₅₀ = 4.2 nM) induces differentiation and apoptosis in cancer cells lines.

Amprolium is an anti-parasitic coccidiostat used in veterinary medicine. Amprolium is a thiamine analog that inhibits thiamine transporters in species of Eimeria, preventing carbohydrate synthesis.

Amprolium is an anti-parasitic coccidiostat used in veterinary medicine. Amprolium is a thiamine analog that inhibits thiamine transporters in species of Eimeria, preventing carbohydrate synthesis.

An inhibitor of DGK (Ki = 3.1 &microM) and DGAT (IC₅₀ = 5.

An inhibitor of DGK (Ki = 3.1 &microM) and DGAT (IC₅₀ = 5.

A bisdeoxy derivative of coelenterazine that produces an emission peak near 400 nm following conversion by Renilla luciferase commonly used in BRET2 protocols to evaluate protein-protein interactions.

A bisdeoxy derivative of coelenterazine that produces an emission peak near 400 nm following conversion by Renilla luciferase commonly used in BRET2 protocols to evaluate protein-protein interactions.