Biologically Active Small Molecules

A colchicine derivative that inhibits tubulin polymerization (IC₅₀ = 2.1 &muM) with low toxicity suppresses microtubule dynamicity, inhibits cell migration, blocks microtubule assembly, and arrests cells in metaphase used to

A colchicine derivative that inhibits tubulin polymerization (IC₅₀ = 2.1 &muM) with low toxicity suppresses microtubule dynamicity, inhibits cell migration, blocks microtubule assembly, and arrests cells in metaphase used to

Inhibits microtubule polymerization (IC₅₀ =3.2 &muM) by binding to tubulin, which disrupts spindle formation during mitosis blocks the growth of MCF-7 human breast carcinoma cells (IC₅₀ = 13 nM) inhibits neutrophil motility

Inhibits microtubule polymerization (IC₅₀ =3.2 &muM) by binding to tubulin, which disrupts spindle formation during mitosis blocks the growth of MCF-7 human breast carcinoma cells (IC₅₀ = 13 nM) inhibits neutrophil motility

Inhibits microtubule polymerization (IC₅₀ =3.2 &muM) by binding to tubulin, which disrupts spindle formation during mitosis blocks the growth of MCF-7 human breast carcinoma cells (IC₅₀ = 13 nM) inhibits neutrophil motility

A polypeptide antibiotic effective against Gram-negative bacteria, including P. aeruginosa, A. baumannii, and K. pneumoniae.

A polypeptide antibiotic effective against Gram-negative bacteria, including P. aeruginosa, A. baumannii, and K. pneumoniae.

A polypeptide antibiotic effective against Gram-negative bacteria, including P. aeruginosa, A. baumannii, and K. pneumoniae.

A polypeptide antibiotic effective against Gram-negative bacteria, including P. aeruginosa, A. baumannii, and K. pneumoniae.

A prodrug for colistin (also known as polymyxin E), an antibiotic that is effective against most Gram-negative bacteria but suffers from nephro- and neurotoxicity used against infections caused by multidrug resistant Gram-negative bacteria.

A prodrug for colistin (also known as polymyxin E), an antibiotic that is effective against most Gram-negative bacteria but suffers from nephro- and neurotoxicity used against infections caused by multidrug resistant Gram-negative bacteria.

A potent tubulin polymerization inhibitor that reduces tumor growth in P-388 (leukemia), SK-N-SH (neuroblast), BXPC-3 (pancreas), NCI-H460 (lung), and DU-145 (prostate) cell lines with ED50 values of 0.0029, 0.