Biologically Active Small Molecules

A natural bacterial product that activates GPR132 (also known as G2A) with an EC₅₀ value of 11.8 &microM.

A natural bacterial product that activates GPR132 (also known as G2A) with an EC₅₀ value of 11.8 &microM.

A natural bacterial product that activates GPR132 (also known as G2A) with an EC₅₀ value of 11.8 &microM.

Butylated hydroxyanisole (BHA) exhibits antioxidative and anticancer activities. BHA is commercially used as a food additive or preservative, as its free radical scavenging ability stabilizes free radicals and prevents food spoilage.

Butylated hydroxyanisole (BHA) exhibits antioxidative and anticancer activities. BHA is commercially used as a food additive or preservative, as its free radical scavenging ability stabilizes free radicals and prevents food spoilage.

A highly potent inhibitor of the tyrosine kinase activity of EGFR (IC₅₀ = 0.006 nM) inhibits EGFR activity in pancreatic cancer cell lines and induces the differentiation of rat mesenchymal stem cells.

A highly potent inhibitor of the tyrosine kinase activity of EGFR (IC₅₀ = 0.006 nM) inhibits EGFR activity in pancreatic cancer cell lines and induces the differentiation of rat mesenchymal stem cells.

A potent, cell-permeable, and selective inhibitor of &gamma-secretase, blocking the cleavage of both APP and Notch CTFs with IC₅₀ values of ~0.3 nM induces neuronal differentiation, impairs ovarian folliculogenesis, and suppresses

A potent, cell-permeable, and selective inhibitor of &gamma-secretase, blocking the cleavage of both APP and Notch CTFs with IC₅₀ values of ~0.3 nM induces neuronal differentiation, impairs ovarian folliculogenesis, and suppresses

Blocks lysosomal acidification through selective inhibition of the V-type ATPase (EC50 = 2.1-2.

Blocks lysosomal acidification through selective inhibition of the V-type ATPase (EC50 = 2.1-2.

Blocks lysosomal acidification through selective inhibition of the V-type ATPase (EC50 = 2.1-2.