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19170-10A selective inhibitor of PDGFR&beta and PDGFR&alpha kinases (IC<sub>50</sub>s = 1 and 10 nM, respectively) antiangiogenic and antitumor activity in several in vivo tumor models.
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19170-5A selective inhibitor of PDGFR&beta and PDGFR&alpha kinases (IC<sub>50</sub>s = 1 and 10 nM, respectively) antiangiogenic and antitumor activity in several in vivo tumor models.
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11598-10A potent, cell-permeable inhibitor of all JAK isoforms (IC50 = 6.1, 12, and 8.0 nM for JAK1, JAK2, and JAK3, respectively) useful in ameliorating inflammatory or autoimmune components of a host of diseases.
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11598-25A potent, cell-permeable inhibitor of all JAK isoforms (IC50 = 6.1, 12, and 8.0 nM for JAK1, JAK2, and JAK3, respectively) useful in ameliorating inflammatory or autoimmune components of a host of diseases.
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11598-5A potent, cell-permeable inhibitor of all JAK isoforms (IC50 = 6.1, 12, and 8.0 nM for JAK1, JAK2, and JAK3, respectively) useful in ameliorating inflammatory or autoimmune components of a host of diseases.
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11598-50A potent, cell-permeable inhibitor of all JAK isoforms (IC50 = 6.1, 12, and 8.0 nM for JAK1, JAK2, and JAK3, respectively) useful in ameliorating inflammatory or autoimmune components of a host of diseases.
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19172-1A selective inhibitor of HER2/ErbB2 (IC<sub>50</sub> = 10 nM) inhibits the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 (IC<sub>50</sub>s = 0.25 and 0.
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19172-10A selective inhibitor of HER2/ErbB2 (IC<sub>50</sub> = 10 nM) inhibits the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 (IC<sub>50</sub>s = 0.25 and 0.
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19172-25A selective inhibitor of HER2/ErbB2 (IC<sub>50</sub> = 10 nM) inhibits the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 (IC<sub>50</sub>s = 0.25 and 0.
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19172-5A selective inhibitor of HER2/ErbB2 (IC<sub>50</sub> = 10 nM) inhibits the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 (IC<sub>50</sub>s = 0.25 and 0.
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13183-1A selective inhibitor of PDE4 (IC<sub>50</sub> = 1.27 &muM for PDE4 versus >100 &muM for PDE1, PDE2, PDE3, and PDE5) inhibits eosinophil superoxide production (IC<sub>50</sub> induced TNF&alpha release from monocytes, (IC<sub>50</sub> = 0.
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13183-10A selective inhibitor of PDE4 (IC<sub>50</sub> = 1.27 &muM for PDE4 versus >100 &muM for PDE1, PDE2, PDE3, and PDE5) inhibits eosinophil superoxide production (IC<sub>50</sub> induced TNF&alpha release from monocytes, (IC<sub>50</sub> = 0.