Biologically Active Small Molecules

A selective EZH2 inhibitor (IC₅₀s = 0.24, 0.

A selective EZH2 inhibitor (IC₅₀s = 0.24, 0.

A primary amide analog of (+)-JQ1 which has shown superior bioavailability with oral or i.p.

A primary amide analog of (+)-JQ1 which has shown superior bioavailability with oral or i.p.

A primary amide analog of (+)-JQ1 which has shown superior bioavailability with oral or i.p.

A primary amide analog of (+)-JQ1 which has shown superior bioavailability with oral or i.p.

A selective EZH2 inhibitor (IC₅₀s = 0.5 and 2.

A selective EZH2 inhibitor (IC₅₀s = 0.5 and 2.

A selective EZH2 inhibitor (IC₅₀s = 0.5 and 2.

A selective EZH2 inhibitor (IC₅₀s = 0.5 and 2.

A lipoic acid analog that inhibits &alpha-ketoglutarate dehydrogenase, particularly in tumor cells induces a strong mitochondrial burst of reactive oxygen species at 60-240 &microM, resulting in cell death demonstrates both in vitro and in vivo

A lipoic acid analog that inhibits &alpha-ketoglutarate dehydrogenase, particularly in tumor cells induces a strong mitochondrial burst of reactive oxygen species at 60-240 &microM, resulting in cell death demonstrates both in vitro and in vivo