Biologically Active Small Molecules

A lipoic acid analog that inhibits &alpha-ketoglutarate dehydrogenase, particularly in tumor cells induces a strong mitochondrial burst of reactive oxygen species at 60-240 &microM, resulting in cell death demonstrates both in vitro and in vivo

A lipoic acid analog that inhibits &alpha-ketoglutarate dehydrogenase, particularly in tumor cells induces a strong mitochondrial burst of reactive oxygen species at 60-240 &microM, resulting in cell death demonstrates both in vitro and in vivo

Specifically inhibits Gcn5-dependent acetylation of histone H3K14 at a concentration of 0.8 mM both in vitro and in vivo.

Specifically inhibits Gcn5-dependent acetylation of histone H3K14 at a concentration of 0.8 mM both in vitro and in vivo.

A Gcn5 and pCAF HAT inhibitor.

A Gcn5 and pCAF HAT inhibitor.

A Gcn5 and pCAF HAT inhibitor.

An affinity probe for amyloid-&beta.

An affinity probe for amyloid-&beta.

An affinity probe for amyloid-&beta.

An affinity probe for amyloid-&beta.

A fluorescent affinity probe for amyloid-&beta.