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Add to Cart The item has been added12087-50A potent, orally bioavailable, ATP-competitive small-molecule dual inhibitor of c-MET (IC<sub>50</sub> = 8 nM) and ALK (IC<sub>50</sub> = 20 nM) receptor tyrosine kinases shows antitumor efficacy in multiple tumor models implanted in athymic mice -
Add to Cart The item has been added15337-1A pan inhibitor PKD (IC<sub>50</sub>s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively) blocks cell proliferation, induces apoptosis, and reduces the viability of pancreatic cancer cells both in vitro and in vivo. -
Add to Cart The item has been added15337-10A pan inhibitor PKD (IC<sub>50</sub>s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively) blocks cell proliferation, induces apoptosis, and reduces the viability of pancreatic cancer cells both in vitro and in vivo. -
Add to Cart The item has been added15337-5A pan inhibitor PKD (IC<sub>50</sub>s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively) blocks cell proliferation, induces apoptosis, and reduces the viability of pancreatic cancer cells both in vitro and in vivo. -
Add to Cart The item has been added18532-1A pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC<sub>50</sub>s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively) decreases VEGF-induced endothelial migration, -
Add to Cart The item has been added18532-10A pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC<sub>50</sub>s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively) decreases VEGF-induced endothelial migration, -
Add to Cart The item has been added18532-25A pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC<sub>50</sub>s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively) decreases VEGF-induced endothelial migration, -
Add to Cart The item has been added18532-5A pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC<sub>50</sub>s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively) decreases VEGF-induced endothelial migration, -
Add to Cart The item has been added16987-10A natural quinoid diterpene that, at 10-20 µM, stimulates AMPK in C2C12 myotubes and activates p38 MAPK in DU145 cells inhibits SHP2 in vitro (IC<sub>50</sub> = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 -
Add to Cart The item has been added16987-25A natural quinoid diterpene that, at 10-20 µM, stimulates AMPK in C2C12 myotubes and activates p38 MAPK in DU145 cells inhibits SHP2 in vitro (IC<sub>50</sub> = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 -
Add to Cart The item has been added16987-5A natural quinoid diterpene that, at 10-20 µM, stimulates AMPK in C2C12 myotubes and activates p38 MAPK in DU145 cells inhibits SHP2 in vitro (IC<sub>50</sub> = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 -
Add to Cart The item has been added16987-50A natural quinoid diterpene that, at 10-20 µM, stimulates AMPK in C2C12 myotubes and activates p38 MAPK in DU145 cells inhibits SHP2 in vitro (IC<sub>50</sub> = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3
