Biologically Active Small Molecules

A water soluble, cyclic octapeptide which acts as a receptor antagonist that is selective for the &micro opioid receptor (IC₅₀ = 3.5 nM) over the &delta receptor (IC₅₀ = 4,500 nM) a poor antagonist of the somatostatin

An amide derivative that selectively activates the HAT p300, with maximal activation at 275 &microM.

An amide derivative that selectively activates the HAT p300, with maximal activation at 275 &microM.

An orally bioavailable, blood-brain barrier permeable complex used in cellular imaging experiments to selectively label hypoxic tissue improves locomotor function and survival in a transgenic ALS mouse model by delivering copper specifically to

An orally bioavailable, blood-brain barrier permeable complex used in cellular imaging experiments to selectively label hypoxic tissue improves locomotor function and survival in a transgenic ALS mouse model by delivering copper specifically to

An orally bioavailable, blood-brain barrier permeable complex used in cellular imaging experiments to selectively label hypoxic tissue improves locomotor function and survival in a transgenic ALS mouse model by delivering copper specifically to

An orally bioavailable, blood-brain barrier permeable complex used in cellular imaging experiments to selectively label hypoxic tissue improves locomotor function and survival in a transgenic ALS mouse model by delivering copper specifically to

A plant-derived steroidal triterpene that induces cell cycle arrest or apoptosis in a range of cancer cell lines inhibits the growth of several breast cancer cell lines (IC₅₀s = 18-50 nM) suppresses the growth of tumors developed from

A plant-derived steroidal triterpene that induces cell cycle arrest or apoptosis in a range of cancer cell lines inhibits the growth of several breast cancer cell lines (IC₅₀s = 18-50 nM) suppresses the growth of tumors developed from

A plant-derived steroidal triterpene that induces cell cycle arrest or apoptosis in a range of cancer cell lines inhibits the growth of several breast cancer cell lines (IC₅₀s = 18-50 nM) suppresses the growth of tumors developed from

A plant-derived steroidal triterpene that induces cell cycle arrest or apoptosis in a range of cancer cell lines inhibits the growth of several breast cancer cell lines (IC₅₀s = 18-50 nM) suppresses the growth of tumors developed from

A potent inhibitor of the STAT3/JAK signaling pathway suppresses levels of tyrosine phosphorylated STAT3, STAT3 DNA binding and STAT3-mediated gene transcription suppresses tumor growth in vivo.