Biologically Active Small Molecules

A small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA-patient fibroblasts by 50% at 18 &microM increases phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of

A small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA-patient fibroblasts by 50% at 18 &microM increases phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of

A potent antagonist of the PAF receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC₅₀ values of 75 and 170 nM, respectively prevents PAF-induced hypotension in rats, while not blocking hypotension

A potent antagonist of the PAF receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC₅₀ values of 75 and 170 nM, respectively prevents PAF-induced hypotension in rats, while not blocking hypotension

A potent antagonist of the PAF receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC₅₀ values of 75 and 170 nM, respectively prevents PAF-induced hypotension in rats, while not blocking hypotension

A selective, reversible inhibitor of ALDH2 (IC₅₀ = 29 nM) reduces excessive alcohol drinking in alcohol-preferring rats, prevents self-administration of alcohol in Long-Evans rats, and produces anxiolytic effects.

A selective, reversible inhibitor of ALDH2 (IC₅₀ = 29 nM) reduces excessive alcohol drinking in alcohol-preferring rats, prevents self-administration of alcohol in Long-Evans rats, and produces anxiolytic effects.

A selective, reversible inhibitor of ALDH2 (IC₅₀ = 29 nM) reduces excessive alcohol drinking in alcohol-preferring rats, prevents self-administration of alcohol in Long-Evans rats, and produces anxiolytic effects.

A selective, reversible inhibitor of ALDH2 (IC₅₀ = 29 nM) reduces excessive alcohol drinking in alcohol-preferring rats, prevents self-administration of alcohol in Long-Evans rats, and produces anxiolytic effects.

CWHM12 is an analog of RGD peptide (Item No. 14501), a tripeptide that inhibits integrin-ligand interactions in studies related to cell adhesion, migration, growth, and differentiation.

CWHM12 is an analog of RGD peptide (Item No. 14501), a tripeptide that inhibits integrin-ligand interactions in studies related to cell adhesion, migration, growth, and differentiation.

CWHM12 is an analog of RGD peptide (Item No. 14501), a tripeptide that inhibits integrin-ligand interactions in studies related to cell adhesion, migration, growth, and differentiation.