Biologically Active Small Molecules

A potent, reversible, orally bioavailable inhibitor of Pim-1, -2, and -3 (IC₅₀s = 5, 25, and 16 nM, respectively) dose-dependently blocks the phosphorylation of the Pim targets Bad, 4E-BP1, and NKX3.1 acts synergistically with

A natural anthocyanidin with significant antioxidant activity has vasoprotective effects and can interfere with inflammation, carcinogenesis, obesity, and diabetes.

A natural anthocyanidin with significant antioxidant activity has vasoprotective effects and can interfere with inflammation, carcinogenesis, obesity, and diabetes.

A natural anthocyanidin with significant antioxidant activity has vasoprotective effects and can interfere with inflammation, carcinogenesis, obesity, and diabetes.

A natural anthocyanidin with significant antioxidant activity has vasoprotective effects and can interfere with inflammation, carcinogenesis, obesity, and diabetes.

A central second messenger in cell signaling, propagating signals from receptors to downstream pathways generated from ATP by several adenylate cyclase enzymes, which are modulated by G protein-coupled receptors.

A central second messenger in cell signaling, propagating signals from receptors to downstream pathways generated from ATP by several adenylate cyclase enzymes, which are modulated by G protein-coupled receptors.

A central second messenger in cell signaling, propagating signals from receptors to downstream pathways generated from ATP by several adenylate cyclase enzymes, which are modulated by G protein-coupled receptors.

A second messenger produced by bacteria but not by mammals impacts bacterial cell growth, cell wall homeostasis, pathogenicity, and other cellular functions triggers the expression of interferon genes in mammalian cells.

A second messenger produced by bacteria but not by mammals impacts bacterial cell growth, cell wall homeostasis, pathogenicity, and other cellular functions triggers the expression of interferon genes in mammalian cells.

A second messenger produced by bacteria but not by mammals impacts bacterial cell growth, cell wall homeostasis, pathogenicity, and other cellular functions triggers the expression of interferon genes in mammalian cells.

An important second messenger in bacteria involved in biofilm formation, motility, virulence, and cell cycling also has functions in eukaryotic cells.