Biologically Active Small Molecules

An important second messenger in bacteria involved in biofilm formation, motility, virulence, and cell cycling also has functions in eukaryotic cells.

A second messenger that is biosynthesized from GTP by guanylate cyclases activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation,

A second messenger that is biosynthesized from GTP by guanylate cyclases activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation,

A stable analog of PFT-&alpha, formed by the condensation of PFT-&alpha in solution inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC₅₀ = 23, 77, and 103 &muM, respectively) induces autophagy in HCT116 cells

A stable analog of PFT-&alpha, formed by the condensation of PFT-&alpha in solution inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC₅₀ = 23, 77, and 103 &muM, respectively) induces autophagy in HCT116 cells

A stable analog of PFT-&alpha, formed by the condensation of PFT-&alpha in solution inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC₅₀ = 23, 77, and 103 &muM, respectively) induces autophagy in HCT116 cells

A stable analog of PFT-&alpha, formed by the condensation of PFT-&alpha in solution inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC₅₀ = 23, 77, and 103 &muM, respectively) induces autophagy in HCT116 cells

An active metabolite of proguanil, produced by CYP2C19 an inhibitor of dihydrofolate reductase (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively).

An active metabolite of proguanil, produced by CYP2C19 an inhibitor of dihydrofolate reductase (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively).

An active metabolite of proguanil, produced by CYP2C19 an inhibitor of dihydrofolate reductase (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively).

An active metabolite of proguanil, produced by CYP2C19 an inhibitor of dihydrofolate reductase (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively).

An inhibitor of protein synthesis in eukaryotes (IC₅₀ = 5-50 &muM) that functions by interfering with translational elongation can either induce or inhibit apoptosis depending on cell type.