Biologically Active Small Molecules

An immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC₅₀ = 5 nM), which interferes with the nuclear import of NFAT, a transcription factor involved in T cell activation used

An immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC₅₀ = 5 nM), which interferes with the nuclear import of NFAT, a transcription factor involved in T cell activation used

A metabolite of the immunosuppressant drug cyclosporin A that displays about 10% lower immunosuppressant activity than cyclosporin A used as an internal standard for the quantification of cyclosporin A.

A metabolite of the immunosuppressant drug cyclosporin A that displays about 10% lower immunosuppressant activity than cyclosporin A used as an internal standard for the quantification of cyclosporin A.

A natural cyclic undecapeptide that selectively antagonizes the formyl peptide receptor at concentrations ranging from 0.1 to 10 &microM.

A natural cyclic undecapeptide that selectively antagonizes the formyl peptide receptor at concentrations ranging from 0.1 to 10 &microM.

A benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC₅₀ = 3.8 &microM) also a negative modulator of GABAA receptors, reversibly inhibiting both evoked and spontaneous

A benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC₅₀ = 3.8 &microM) also a negative modulator of GABAA receptors, reversibly inhibiting both evoked and spontaneous

A benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC₅₀ = 3.8 &microM) also a negative modulator of GABAA receptors, reversibly inhibiting both evoked and spontaneous

A benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC₅₀ = 3.8 &microM) also a negative modulator of GABAA receptors, reversibly inhibiting both evoked and spontaneous

A cyanobacterial toxin that targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 &microM, respectively), inhibits uridine monophosphate synthase complex activity (Ki = 10 &microM), and induces DNA damage.

A cyanobacterial toxin that targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 &microM, respectively), inhibits uridine monophosphate synthase complex activity (Ki = 10 &microM), and induces DNA damage.