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Add to Cart The item has been added10007867-50A cyanobacterial toxin that targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 µM, respectively), inhibits uridine monophosphate synthase complex activity (Ki = 10 µM), and induces DNA damage. -
Add to Cart The item has been added14667-1A novel agonist of SIP4 (EC<sub>50</sub> = 56 nM) that displays 37-fold selectivity against S1P5 (EC<sub>50</sub> = 2.1 &muM) and no appreciable activity over the S1P1-3 subtypes at concentrations up to 25 &muM. -
Add to Cart The item has been added14667-10A novel agonist of SIP4 (EC<sub>50</sub> = 56 nM) that displays 37-fold selectivity against S1P5 (EC<sub>50</sub> = 2.1 &muM) and no appreciable activity over the S1P1-3 subtypes at concentrations up to 25 &muM. -
Add to Cart The item has been added14667-5A novel agonist of SIP4 (EC<sub>50</sub> = 56 nM) that displays 37-fold selectivity against S1P5 (EC<sub>50</sub> = 2.1 &muM) and no appreciable activity over the S1P1-3 subtypes at concentrations up to 25 &muM. -
Add to Cart The item has been added14667-50A novel agonist of SIP4 (EC<sub>50</sub> = 56 nM) that displays 37-fold selectivity against S1P5 (EC<sub>50</sub> = 2.1 &muM) and no appreciable activity over the S1P1-3 subtypes at concentrations up to 25 &muM. -
Add to Cart The item has been added16925-1A selective SIP1 agonist (EC<sub>50</sub> = 1.35 nM) activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 (EC<sub>50</sub> = 46 nM) induces S1P1-dependent lymphopenia in mice, decreasing B and T cells by 65 -
Add to Cart The item has been added16925-10A selective SIP1 agonist (EC<sub>50</sub> = 1.35 nM) activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 (EC<sub>50</sub> = 46 nM) induces S1P1-dependent lymphopenia in mice, decreasing B and T cells by 65 -
Add to Cart The item has been added16925-25A selective SIP1 agonist (EC<sub>50</sub> = 1.35 nM) activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 (EC<sub>50</sub> = 46 nM) induces S1P1-dependent lymphopenia in mice, decreasing B and T cells by 65 -
Add to Cart The item has been added16925-5A selective SIP1 agonist (EC<sub>50</sub> = 1.35 nM) activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 (EC<sub>50</sub> = 46 nM) induces S1P1-dependent lymphopenia in mice, decreasing B and T cells by 65 -
Add to Cart The item has been added17638-1A noncompetitive allosteric agonist of S1P2 (EC<sub>50</sub> = 0.48 &muM) that does not display agonist activity towards S1P1, S1P3, S1P4, or S1P5. -
Add to Cart The item has been added17638-10A noncompetitive allosteric agonist of S1P2 (EC<sub>50</sub> = 0.48 &muM) that does not display agonist activity towards S1P1, S1P3, S1P4, or S1P5. -
Add to Cart The item has been added17638-5A noncompetitive allosteric agonist of S1P2 (EC<sub>50</sub> = 0.48 &muM) that does not display agonist activity towards S1P1, S1P3, S1P4, or S1P5.
