Biologically Active Small Molecules

An antagonist/partial agonist of the androgen receptor (IC₅₀ = 26 nM in humans) that has been shown to have clinical use in androgen-dependent conditions such as prostate cancer, hirsutism, and alopecia suppresses accessory sexual glands

An antagonist/partial agonist of the androgen receptor (IC₅₀ = 26 nM in humans) that has been shown to have clinical use in androgen-dependent conditions such as prostate cancer, hirsutism, and alopecia suppresses accessory sexual glands

An indole-based, time-dependent inhibitor of Icmt (IC₅₀ = i = 0.14 &microM for the final complex) decreases mTOR signaling, accumulation of cells in the G1 phase, and autophagy-mediated cell death in PC3 prostate cancer cells.

An indole-based, time-dependent inhibitor of Icmt (IC₅₀ = i = 0.14 &microM for the final complex) decreases mTOR signaling, accumulation of cells in the G1 phase, and autophagy-mediated cell death in PC3 prostate cancer cells.

An indole-based, time-dependent inhibitor of Icmt (IC₅₀ = i = 0.14 &microM for the final complex) decreases mTOR signaling, accumulation of cells in the G1 phase, and autophagy-mediated cell death in PC3 prostate cancer cells.

An organic disulfide that inhibits TGM2 with an IC₅₀ value of approximately 2.5 mM neuroprotective in mouse models of Huntington&rsquos disease also inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a

An organic disulfide that inhibits TGM2 with an IC₅₀ value of approximately 2.5 mM neuroprotective in mouse models of Huntington&rsquos disease also inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a

An organic disulfide that inhibits TGM2 with an IC₅₀ value of approximately 2.5 mM neuroprotective in mouse models of Huntington&rsquos disease also inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a

An organic disulfide that inhibits TGM2 with an IC₅₀ value of approximately 2.5 mM neuroprotective in mouse models of Huntington&rsquos disease also inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a

N-Acetyl-L-cysteine exhibits antioxidative, mucolytic, anti-inflammatory, antiviral, antipsychotic, and neuromodulatory activities. N-Acetyl-L-cysteine has clinically been used to treat acetaminophen overdose it is occasionally commercially sold as

N-Acetyl-L-cysteine exhibits antioxidative, mucolytic, anti-inflammatory, antiviral, antipsychotic, and neuromodulatory activities. N-Acetyl-L-cysteine has clinically been used to treat acetaminophen overdose it is occasionally commercially sold as

N-Acetyl-L-cysteine exhibits antioxidative, mucolytic, anti-inflammatory, antiviral, antipsychotic, and neuromodulatory activities. N-Acetyl-L-cysteine has clinically been used to treat acetaminophen overdose it is occasionally commercially sold as