Biologically Active Small Molecules

A cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis,

A cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis,

A cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis,

A cell-permeable inhibitor of actin polymerization that has been shown to be 10 times less toxic in mice than cytochalasin D.

A cell-permeable inhibitor of actin polymerization that has been shown to be 10 times less toxic in mice than cytochalasin D.

A cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit polymerization at concentrations as low as 0.2 &microM.

A cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit polymerization at concentrations as low as 0.2 &microM.

A cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit polymerization at concentrations as low as 0.2 &microM.

Inhibits actin polymerization potently and selectively inhibits the growth of endothelial cells (IC50 1 protease activity.

Inhibits actin polymerization potently and selectively inhibits the growth of endothelial cells (IC50 1 protease activity.

Inhibits actin polymerization potently and selectively inhibits the growth of endothelial cells (IC50 1 protease activity.

A potent inhibitor of actin incorporation into filaments also increases the steady-state diffusion coefficients of filaments, suggesting that it stimulates filament shortening.