Biologically Active Small Molecules

A potent inhibitor of actin incorporation into filaments also increases the steady-state diffusion coefficients of filaments, suggesting that it stimulates filament shortening.

A deacetylated analog of cytochalasin H that weakly inhibits actin assembly but significantly alters mitotic spindle microtubule organization and kinetochore structure suppresses the production of reactive oxygen species by stimulated human

A deacetylated analog of cytochalasin H that weakly inhibits actin assembly but significantly alters mitotic spindle microtubule organization and kinetochore structure suppresses the production of reactive oxygen species by stimulated human

Antimycin A was initially produced by Streptomyces. Antimycin A binds cytochrome c reductase, inhibiting electron transport chain activity, oxidative phosphorylation, and ATP synthesis.

Antimycin A was initially produced by Streptomyces. Antimycin A binds cytochrome c reductase, inhibiting electron transport chain activity, oxidative phosphorylation, and ATP synthesis.

A naturally occurring agonist for the nuclear receptor Nur77 (IC₅₀ = 0.278 nM) induces apoptosis in cancer cells and retards xenograft tumor growth induces genes related to gluconeogenesis and decreases atherosclerosis progression in

A naturally occurring agonist for the nuclear receptor Nur77 (IC₅₀ = 0.278 nM) induces apoptosis in cancer cells and retards xenograft tumor growth induces genes related to gluconeogenesis and decreases atherosclerosis progression in

A naturally occurring agonist for the nuclear receptor Nur77 (IC₅₀ = 0.278 nM) induces apoptosis in cancer cells and retards xenograft tumor growth induces genes related to gluconeogenesis and decreases atherosclerosis progression in

A naturally occurring agonist for the nuclear receptor Nur77 (IC₅₀ = 0.278 nM) induces apoptosis in cancer cells and retards xenograft tumor growth induces genes related to gluconeogenesis and decreases atherosclerosis progression in

A natural antitumor inhibitor of cell adhesion to extracellular matrix that potently and selectively inhibits PP2A (IC₅₀ = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.

CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2 IC₅₀s = 1.28 and 1.

CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2 IC₅₀s = 1.28 and 1.