Biologically Active Small Molecules

CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2 IC₅₀s = 1.28 and 1.

CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2 IC₅₀s = 1.28 and 1.

A selective inhibitor of PI3K&gamma

A selective inhibitor of PI3K&gamma

A selective inhibitor of PI3K&gamma

A selective inhibitor of PI3K&gamma

An aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES.

An aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES.

An aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES.

An aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES.

A cell-permeant inhibitor of CK1 (IC₅₀ = 200 nM from S. pombe, 300 nM for CK1&delta) only weakly affects the activities of a panel of kinases tested.

A cell-permeant inhibitor of CK1 (IC₅₀ = 200 nM from S. pombe, 300 nM for CK1&delta) only weakly affects the activities of a panel of kinases tested.