Biologically Active Small Molecules

An inhibitor of &gamma-secretase, blocking the production of total A&beta in human primary neuronal cultures with an IC₅₀ value of 115 nM and A&beta42 with an IC₅₀ value of 200 nM reduces brain levels of A&beta in vivo

An inhibitor of &gamma-secretase, blocking the production of total A&beta in human primary neuronal cultures with an IC₅₀ value of 115 nM and A&beta42 with an IC₅₀ value of 200 nM reduces brain levels of A&beta in vivo

An inhibitor of &gamma-secretase, blocking the production of total A&beta in human primary neuronal cultures with an IC₅₀ value of 115 nM and A&beta42 with an IC₅₀ value of 200 nM reduces brain levels of A&beta in vivo

An inhibitor of &gamma-secretase, blocking the production of total A&beta in human primary neuronal cultures with an IC₅₀ value of 115 nM and A&beta42 with an IC₅₀ value of 200 nM reduces brain levels of A&beta in vivo

A lipopeptide antibiotic effective against resistant Gram-positive bacteria (MIC90s range from 0.25-16 mg/L) alters bacterial plasma membrane potential and redirects the binding of proteins essential for cell division and cell wall synthesis.

A lipopeptide antibiotic effective against resistant Gram-positive bacteria (MIC90s range from 0.25-16 mg/L) alters bacterial plasma membrane potential and redirects the binding of proteins essential for cell division and cell wall synthesis.

A lipopeptide antibiotic effective against resistant Gram-positive bacteria (MIC90s range from 0.25-16 mg/L) alters bacterial plasma membrane potential and redirects the binding of proteins essential for cell division and cell wall synthesis.

A lipopeptide antibiotic effective against resistant Gram-positive bacteria (MIC90s range from 0.25-16 mg/L) alters bacterial plasma membrane potential and redirects the binding of proteins essential for cell division and cell wall synthesis.

A reversible inhibitor of Lp-PLA2 (IC₅₀ = 0.25 nM) that produces sustained inhibition of plasma Lp-PLA2 activity in humans.

A reversible inhibitor of Lp-PLA2 (IC₅₀ = 0.25 nM) that produces sustained inhibition of plasma Lp-PLA2 activity in humans.

A reversible inhibitor of Lp-PLA2 (IC₅₀ = 0.25 nM) that produces sustained inhibition of plasma Lp-PLA2 activity in humans.

A reversible inhibitor of Lp-PLA2 (IC₅₀ = 0.25 nM) that produces sustained inhibition of plasma Lp-PLA2 activity in humans.