Biologically Active Small Molecules

A TZD that increases the sensitivity of cells to insulin, stimulating insulin-induced PI3K activity at submicromolar concentrations increases insulin effectiveness in obese NIDDM subjects promotes adipocyte differentiation by up-regulating the

A TZD that increases the sensitivity of cells to insulin, stimulating insulin-induced PI3K activity at submicromolar concentrations increases insulin effectiveness in obese NIDDM subjects promotes adipocyte differentiation by up-regulating the

A TZD that increases the sensitivity of cells to insulin, stimulating insulin-induced PI3K activity at submicromolar concentrations increases insulin effectiveness in obese NIDDM subjects promotes adipocyte differentiation by up-regulating the

A TZD that increases the sensitivity of cells to insulin, stimulating insulin-induced PI3K activity at submicromolar concentrations increases insulin effectiveness in obese NIDDM subjects promotes adipocyte differentiation by up-regulating the

A receptor antagonist acting at the muscarinic receptors (Ki = 5.5, 47, 0.84, 8.6, and 2.3 nM for M1 through M5, respectively) effective in treating problems related to the lower urinary tract.

A receptor antagonist acting at the muscarinic receptors (Ki = 5.5, 47, 0.84, 8.6, and 2.3 nM for M1 through M5, respectively) effective in treating problems related to the lower urinary tract.

A receptor antagonist acting at the muscarinic receptors (Ki = 5.5, 47, 0.84, 8.6, and 2.3 nM for M1 through M5, respectively) effective in treating problems related to the lower urinary tract.

A receptor antagonist acting at the muscarinic receptors (Ki = 5.5, 47, 0.84, 8.6, and 2.3 nM for M1 through M5, respectively) effective in treating problems related to the lower urinary tract.

A second generation protease inhibitor that supresses the replication of various strains of HIV-1 (IC₅₀s = 3-30 nM) inhibits both cell-free diffusion and cell-to-cell spread of HIV-1 with IC₅₀ values of 2.5 and 2.

A second generation protease inhibitor that supresses the replication of various strains of HIV-1 (IC₅₀s = 3-30 nM) inhibits both cell-free diffusion and cell-to-cell spread of HIV-1 with IC₅₀ values of 2.5 and 2.

A second generation protease inhibitor that supresses the replication of various strains of HIV-1 (IC₅₀s = 3-30 nM) inhibits both cell-free diffusion and cell-to-cell spread of HIV-1 with IC₅₀ values of 2.5 and 2.

A selective activator of PKM2 (AC₅₀ = 38 nM in vitro, EC₅₀ = 19.6 &microM in cells) converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins.