Biologically Active Small Molecules

A non-lipid agonist of LPA2 (EC₅₀ = 0.10 &microM) that is without effect at other LPA receptor subtypes protects IEC-6 cells against caspase activation and apoptosis following irradiation increases the survival of mice suffering from

A &gamma-secretase inhibitor that blocks Notch processing (IC₅₀ = 1.7 nM) reduces A&beta40 levels by 71% in an APP transgenic mouse model within 4 hours after a single 100 &muM/kg dose.

A &gamma-secretase inhibitor that blocks Notch processing (IC₅₀ = 1.7 nM) reduces A&beta40 levels by 71% in an APP transgenic mouse model within 4 hours after a single 100 &muM/kg dose.

A &gamma-secretase inhibitor that blocks Notch processing (IC₅₀ = 1.7 nM) reduces A&beta40 levels by 71% in an APP transgenic mouse model within 4 hours after a single 100 &muM/kg dose.

A FFAR1 (GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid with IC₅₀ values of 6.28, 5.

A FFAR1 (GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid with IC₅₀ values of 6.28, 5.

A FFAR1 (GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid with IC₅₀ values of 6.28, 5.

A FFAR1 (GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid with IC₅₀ values of 6.28, 5.

A MS-cleavable crosslinking reagent (18&Aring in length) that contains two intrinsic positive charges, which allow cross-linked peptides to fragment into their component peptides by collision-induced dissociation or in-source decay.

A MS-cleavable crosslinking reagent (18&Aring in length) that contains two intrinsic positive charges, which allow cross-linked peptides to fragment into their component peptides by collision-induced dissociation or in-source decay.

A MS-cleavable crosslinking reagent (18&Aring in length) that contains two intrinsic positive charges, which allow cross-linked peptides to fragment into their component peptides by collision-induced dissociation or in-source decay.

A prominent member of a class of reactive LO-catalyzed peroxidative decomposition products of unsaturated fatty acids that are formed when diatoms are crushed or eaten.