Biologically Active Small Molecules

A potent fluoroquinolone antibiotic.

A natural plant pigment which induces the release of nitric oxide by vascular endothelium, causing vasorelaxation inhibits signaling through EGFRs, suppressing the expression of ER&alpha and inducing both apoptosis and autophagy at a dose of 1-40

A natural plant pigment which induces the release of nitric oxide by vascular endothelium, causing vasorelaxation inhibits signaling through EGFRs, suppressing the expression of ER&alpha and inducing both apoptosis and autophagy at a dose of 1-40

A natural plant pigment which induces the release of nitric oxide by vascular endothelium, causing vasorelaxation inhibits signaling through EGFRs, suppressing the expression of ER&alpha and inducing both apoptosis and autophagy at a dose of 1-40

A small molecule that binds to the farnesyl-binding pocket of PDE&delta (Kd = 41 nM) in cells thus inhibiting its interaction with KRAS and disrupting RAS signaling reduces proliferation and increases cell death of Panc-Tu-I tumor cells at 5 &muM

A small molecule that binds to the farnesyl-binding pocket of PDE&delta (Kd = 41 nM) in cells thus inhibiting its interaction with KRAS and disrupting RAS signaling reduces proliferation and increases cell death of Panc-Tu-I tumor cells at 5 &muM

A small molecule that binds to the farnesyl-binding pocket of PDE&delta (Kd = 41 nM) in cells thus inhibiting its interaction with KRAS and disrupting RAS signaling reduces proliferation and increases cell death of Panc-Tu-I tumor cells at 5 &muM

A natural demethoxy derivative of curcumin suppresses proliferation in cancer cells at 50-100 &muM down-regulates p300 and inhibits LPS-induced iNOS expression.

A natural demethoxy derivative of curcumin suppresses proliferation in cancer cells at 50-100 &muM down-regulates p300 and inhibits LPS-induced iNOS expression.

A natural demethoxy derivative of curcumin suppresses proliferation in cancer cells at 50-100 &muM down-regulates p300 and inhibits LPS-induced iNOS expression.

A natural demethoxy derivative of curcumin suppresses proliferation in cancer cells at 50-100 &muM down-regulates p300 and inhibits LPS-induced iNOS expression.

,p>Decitabine is a deoxycytidine analog that is incorporated into DNA, inhibiting DNA methyltransferase (DNMT1/3A/3B) activity. This demethylating agent is clinically used to treat myelodysplastic syndromes.