Biologically Active Small Molecules

An intracellular iron chelator and an inhibitor of topoisomerase II&alpha that is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury scavenges hydroxyl (IC₅₀ = 2.1 mM), superoxide

A modulator of plant signaling.

A modulator of plant signaling.

A modulator of plant signaling.

An orally available inverse agonist of PPAR&beta/&delta (IC₅₀ = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC₅₀ = 9.5 nM).

An orally available inverse agonist of PPAR&beta/&delta (IC₅₀ = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC₅₀ = 9.5 nM).

An orally available inverse agonist of PPAR&beta/&delta (IC₅₀ = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC₅₀ = 9.5 nM).

An orally available inverse agonist of PPAR&beta/&delta (IC₅₀ = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC₅₀ = 9.5 nM).

A fluorescent dye for noninvasive measurement of changes in membrane voltage excitation and emission maxima of ~467 and 631 nm, respectively, when incorporated into the lipid bilayer.

A fluorescent dye for noninvasive measurement of changes in membrane voltage excitation and emission maxima of ~467 and 631 nm, respectively, when incorporated into the lipid bilayer.

A fluorescent dye for noninvasive measurement of changes in membrane voltage excitation and emission maxima of ~467 and 631 nm, respectively, when incorporated into the lipid bilayer.

A precursor of rhein, which inhibits IL-1&beta signaling at 10 &microM, suppresses signaling through NF-&kappaB and AP-1, and reduces the expression of MMP-1 and MMP-13 down-regulates the expression of the IL-1&beta receptor, enhances the