Biologically Active Small Molecules

A fluorogenic probe that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19) used to detect changes in CYP catalytic activity caused by drugs or disease.

A fluorogenic probe that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19) used to detect changes in CYP catalytic activity caused by drugs or disease.

A fluorogenic probe that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19) used to detect changes in CYP catalytic activity caused by drugs or disease.

A fluorogenic probe that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19) used to detect changes in CYP catalytic activity caused by drugs or disease.

A compound produced from the metabolism of the organophosphorus solvent, TBP.

A compound produced from the metabolism of the organophosphorus solvent, TBP.

A compound produced from the metabolism of the organophosphorus solvent, TBP.

A compound produced from the metabolism of the organophosphorus solvent, TBP.

A cell-permeable, cGMP analog that activates cGMP-dependent protein kinase.

A cell-permeable, cGMP analog that activates cGMP-dependent protein kinase.

A cell-permeable, cGMP analog that activates cGMP-dependent protein kinase.

Diclofenac is a non-selective COX inhibitor. It inhibits human COX-1 and -2 with IC₅₀ values of 0.9-2.7 and 1.5-20 &microM, respectively. Diclofenac inhibits ovine COX-1 and -2 with IC₅₀ values of 60 and 220 nM, respectively.