Biologically Active Small Molecules

A lipophilic electrophile that has profound effects on oxidative and immunological pathways activates the transcription factor Nrf2, resulting in heme oxygenase-1 expression and increased glutathione levels suppresses the expression of

A lipophilic electrophile that has profound effects on oxidative and immunological pathways activates the transcription factor Nrf2, resulting in heme oxygenase-1 expression and increased glutathione levels suppresses the expression of

A lipophilic electrophile that has profound effects on oxidative and immunological pathways activates the transcription factor Nrf2, resulting in heme oxygenase-1 expression and increased glutathione levels suppresses the expression of

A selective allosteric modulator of M2 receptors that hinders the dissociation of the orthosteric antagonist N-methylscopolamine from the M2 receptor (EC₅₀ = 3 nM).

A water-soluble parthenolide analog inhibits the proliferation and metastasis of various tumor cells by targeting NF-&kappaB, generating reactive oxygen species, and decreasing metalloproteinases 2 and 9 as well as VEGF.

A water-soluble parthenolide analog inhibits the proliferation and metastasis of various tumor cells by targeting NF-&kappaB, generating reactive oxygen species, and decreasing metalloproteinases 2 and 9 as well as VEGF.

A diamidine that is cytotoxic to protozoa affects a variety of enzymes and modulates interactions between nucleic acids and proteins inhibits diamine oxidase with a Ki value of 13 nM enhances the enzymatic activity of ACE2.

A diamidine that is cytotoxic to protozoa affects a variety of enzymes and modulates interactions between nucleic acids and proteins inhibits diamine oxidase with a Ki value of 13 nM enhances the enzymatic activity of ACE2.

A diamidine that is cytotoxic to protozoa affects a variety of enzymes and modulates interactions between nucleic acids and proteins inhibits diamine oxidase with a Ki value of 13 nM enhances the enzymatic activity of ACE2.

A cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 &microM), to depolymerize microtubules and disrupt mitosis.

A cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 &microM), to depolymerize microtubules and disrupt mitosis.

A cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 &microM), to depolymerize microtubules and disrupt mitosis.