Biologically Active Small Molecules

A cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 &microM), to depolymerize microtubules and disrupt mitosis.

A pan-CDK inhibitor (IC₅₀s = 3, 1, 1, and 4 nM for CDK1, CDK2, CDK5, and CDK9, respectively) that inhibits DNA synthesis in A2780 ovarian cancer cells (IC₅₀ = 4 nM) 5 mg/kg prevents tumor growth by 50% in an A2780 ovarian

A pan-CDK inhibitor (IC₅₀s = 3, 1, 1, and 4 nM for CDK1, CDK2, CDK5, and CDK9, respectively) that inhibits DNA synthesis in A2780 ovarian cancer cells (IC₅₀ = 4 nM) 5 mg/kg prevents tumor growth by 50% in an A2780 ovarian

A pan-CDK inhibitor (IC₅₀s = 3, 1, 1, and 4 nM for CDK1, CDK2, CDK5, and CDK9, respectively) that inhibits DNA synthesis in A2780 ovarian cancer cells (IC₅₀ = 4 nM) 5 mg/kg prevents tumor growth by 50% in an A2780 ovarian

An intermediate in the synthesis of jasmonic acid from hexadecatrienoic acid can also be incorporated into glycerolipids and galactolipids, including certain arabidopsides.

An intermediate in the synthesis of jasmonic acid from hexadecatrienoic acid can also be incorporated into glycerolipids and galactolipids, including certain arabidopsides.

An intermediate in the synthesis of jasmonic acid from hexadecatrienoic acid can also be incorporated into glycerolipids and galactolipids, including certain arabidopsides.

An intermediate in the synthesis of jasmonic acid from hexadecatrienoic acid can also be incorporated into glycerolipids and galactolipids, including certain arabidopsides.

An internal standard for the quantification of dinor-OPDA by GC- or LC-MS.

An internal standard for the quantification of dinor-OPDA by GC- or LC-MS.

An internal standard for the quantification of dinor-OPDA by GC- or LC-MS.

A natural steroid sapogenin that has antioxidant and anti-inflammatory activities, is protective against metabolic and cardiovascular diseases, and can have immunomodulatory and estrogenic effects.