Biologically Active Small Molecules

A potent inhibitor of the kinase activity of ALK2 (IC₅₀ = 13-108 nM) disrupts dorsoventral development in zebrafish affects stem cell development, increasing cardiomyocyte progenitors and promoting neurogenesis inhibits the growth of

A 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.

A 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.

A 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.

A cell permeable, competitive inhibitor of HIF-1&alpha prolyl hydroxylase stabilizes HIF-1&alpha expression at normal oxygen tensions in cultured cells at concentrations between 0.1 and 1 mM.

A cell permeable, competitive inhibitor of HIF-1&alpha prolyl hydroxylase stabilizes HIF-1&alpha expression at normal oxygen tensions in cultured cells at concentrations between 0.1 and 1 mM.

A cell permeable, competitive inhibitor of HIF-1&alpha prolyl hydroxylase stabilizes HIF-1&alpha expression at normal oxygen tensions in cultured cells at concentrations between 0.1 and 1 mM.

A cell permeable, competitive inhibitor of HIF-1&alpha prolyl hydroxylase stabilizes HIF-1&alpha expression at normal oxygen tensions in cultured cells at concentrations between 0.1 and 1 mM.

A commonly-used spin trap that reacts with O-, N-, S-, and C-centered radicals, allowing their characterization by electron spin resonance and immuno-spin trapping is water-soluble, rapidly penetrates lipid bilayers, has low toxicity, and can be

A commonly-used spin trap that reacts with O-, N-, S-, and C-centered radicals, allowing their characterization by electron spin resonance and immuno-spin trapping is water-soluble, rapidly penetrates lipid bilayers, has low toxicity, and can be

A commonly-used spin trap that reacts with O-, N-, S-, and C-centered radicals, allowing their characterization by electron spin resonance and immuno-spin trapping is water-soluble, rapidly penetrates lipid bilayers, has low toxicity, and can be

A potent inhibitor of human PDGFR&beta (IC₅₀ = 80 nM).