Biologically Active Small Molecules

A cell-permeable, stable free radical that is commonly used to evaluate the ability of compounds to act as free radical scavengers or hydrogen donors and to measure the antioxidant activity of tissue extracts followed by color change from purple

A probe that reacts stoichiometrically with hydroperoxides to yield the fluorescent molecule DPPP-O also a fluorescent probe for the detection of LDL and cellular oxidation.

A probe that reacts stoichiometrically with hydroperoxides to yield the fluorescent molecule DPPP-O also a fluorescent probe for the detection of LDL and cellular oxidation.

A probe that reacts stoichiometrically with hydroperoxides to yield the fluorescent molecule DPPP-O also a fluorescent probe for the detection of LDL and cellular oxidation.

A probe that reacts stoichiometrically with hydroperoxides to yield the fluorescent molecule DPPP-O also a fluorescent probe for the detection of LDL and cellular oxidation.

A potent inhibitor of PARPs, inhibiting PARP1 with an IC₅₀ value of 40 nM about 10-fold less potent against PARP2.

A potent inhibitor of PARPs, inhibiting PARP1 with an IC₅₀ value of 40 nM about 10-fold less potent against PARP2.

A NO donor with a half-life of three hours at 37&degC, pH 7.4 liberates two moles of NO per mole of parent compound.

A NO donor with a half-life of three hours at 37&degC, pH 7.4 liberates two moles of NO per mole of parent compound.

A NO donor with a half-life of three hours at 37&degC, pH 7.4 liberates two moles of NO per mole of parent compound.

A NO donor with a half-life of three hours at 37&degC, pH 7.4 liberates two moles of NO per mole of parent compound.

Inhibits CKII (IC50 range of 4-10 &microM), Cdk7 (IC50 = ~20 &microM), Cdk8 (IC50 = ~20 &microM), and Cdk9 (IC50 = 3 &microM) inhibits elongation during RNA polymerase II transcription triggers p53-dependent apoptosis of human colon